2011 Annual Report: Genomic Analysis Offers Clues to Most Common Type of Ovarian Cancer


A large-scale genomic analysis led by Memorial Sloan Kettering researchers identified genetic mutations and pathways in the most common and aggressive type of ovarian cancer that distinctly set the disease apart not only from other types of ovarian cancer, but from other solid tumors as well.

The results may be useful in helping doctors assess which experimental targeted therapies are most likely to be effective in individual patients with this type of ovarian cancer, called high-grade serous ovarian cancer.

The research was part of The Cancer Genome Atlas (TCGA) project, a collaborative study funded by the National Institutes of Health that is one of the most comprehensive national efforts to collect, process, and analyze the largest set of tumor samples to date using state-of-the-art genomic and molecular techniques. Memorial Sloan Kettering provided the greatest number of ovarian tumor samples for this study and served as one of the main centers that generated and analyzed the genomic data.