Kaposi’s sarcoma (KS) is a type of cancer that is very common in people with AIDS. Treatments for KS do not cure the disease, and better treatments are needed.
Lenalidomide is used to treat some kinds of blood cancer. In laboratory studies, it stops tumor growth by interfering with the growth of new blood vessels. It also increases the ability of immune cells to kill tumor cells. It has also stopped or slowed the growth of some cancers.
In this study, researchers want to determine the optimal dose of lenalidomide that can be given in people with AIDS-related KS. They also want to see if lenalidomide lowers levels of factors that may make KS tumors grow, and find out what effects it has on immune cells that may help kill KS cells in the body. Investigators want to determine if this drug can make KS tumors shrink or disappear.