Temozolomide is a drug designed to kill cancer cells by damaging DNA. It is currently approved for the treatment of brain tumors such asglioblastoma and astrocytoma. Lapatinib is a drug designed to prevent or slow down the growth of cancer cells by blocking proteins inside the cancer cell. It is approved for the treatment of breast cancer.
In this study, investigators want to evaluate the effectiveness of combining temozolomide and lapatinib to treat patients with recurrent ependymoma. Both drugs are taken orally (by mouth).