Radiation therapy and bevacizumab are both treatments for malignant gliomas. However, giving radiation therapy after an initial course of treatment has been completed can cause scar tissue and neurologic symptoms. Preliminary evidence indicates that giving radiation with bevacizumab may be more effective than giving either treatment alone.
In this study, researchers want to find the highest dose of radiation therapy that can be given with bevacizumab in patients with glioma that has stopped responding to prior radiation therapy and/or chemotherapy. The radiation will be delivered through a targeted approach called stereotactic radiosurgery.