The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and Impact in Newly Diagnosed Patients

Protocol
12-190
Full Title
The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors and Impact in Newly Diagnosed Patients(GOG 244)
Purpose

Lymphedema is a condition in which excess fluid accumulates in a part of the body, typically in an arm or leg. Lymphedema in the legs is a potential side effect of surgery, chemotherapy, and radiation therapy for gynecologic cancer. It can affect people in different ways, and may impair quality of life by causing discomfort.

In this study, researchers are examining the incidence of and risk factors for lymphedema of the legs in patients who will be undergoing surgery for cervical, vulvar, or uterine cancer, and assessing the impact of this condition on patients’ quality of life. Participants will have physical exams and complete questionnaires before and after surgery.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must be scheduled to undergo surgery for stage I-II cervical or uterine cancer or stage I-IV vulvar cancer. The surgery must include full pelvic lymphadenectomy (removal of several pelvic lymph nodes).
  • Patients who have had prior radiation therapy to the pelvis, groin area, or legs may not participate.
  • Patients who have had prior groin, hip, knee, or ankle surgery may not participate.

For more information about this study and to inquire about eligibility, please contact Dr. Mario Leitao at 212-639-3987.

Disease(s)
Cervical Cancer
Quality of Life
Uterine (Endometrial) Cancer
Vulvar Cancer
Related Diseases