Giving chemotherapy directly into the abdomen after surgery is is a widely practiced treatment for cancers of the appendix, colon, or rectum that have spread to the abdominal lining (peritoneum). It is given to kill any lingering cancer cells and reduce the chance of a recurrence or further cancer spread. In this study, researchers are comparing two forms of such “intraperitoneal” chemotherapy given after surgery for patients with these cancers. Patients will be randomly assigned to receive one form of chemotherapy or the other, but not both.
One group of patients will receive early post-operative intraperitoneal chemotherapy (EPIC), in which the drugs floxuridine and leucovorin are delivered through a catheter into the abdomen for three days. Patients stay in the hospital during this time to both receive the chemotherapy and recover from the surgery.
The second group of patients will receive heated (hyperthermic) intraperitoneal chemotherapy (HIPEC), using the drug mitomycin, which is delivered into the abdomen through a catheter for 100 minutes after the tumor removal surgery is completed. Heating the chemotherapy may sensitize cancer cells to the effects of the chemotherapy.