In addition to my clinical and research responsibilities at Memorial Sloan-Kettering, I am a professor of medicine at Weill Cornell Medical College. I am also active in oncology issues on a national level. In 1990, I served as a member of the Oncology Drug Advisory Committee, and I have held various positions at the American Society of Clinical Oncology (ASCO). I was one of ASCO's directors from 1990 to 1993; chairperson of the Membership Committee from 1986 to 1989; chairperson of the Special Awards Committee from 1991to 1995; a member of the ASCO Grant Selection Committee from 2003 to 2004; and a member of the CEA Tumor Marker Panel. In addition, I was principal investigator of a national CALGB protocol evaluating regional liver therapy versus systemic therapy in patients whose disease had spread from the colon to the liver. The study demonstrated a significant increase in survival with regional therapy. I am also a scientific reviewer for many journals and on the editorial board of three journals.