Cetuximab is a drug used to treat head and neck cancer. It works by blocking a protein called the epidermal growth factor receptor and preventing cancer cells from receiving the message to grow and multiply. In this study, researchers want to determine if adding an investigational drug called BYL719 to cetuximab treatment is more effective than cetuximab alone for treating head and neck cancers that have come back or spread after prior therapy.
BYL719 is an inhibitor of PI3 kinase, an enzyme which fuels the growth of several types of cancer. It is taken orally (by mouth). Cetuximab is given intravenously (by vein). Patients in this study will be randomly assigned to receive cetuximab plus BYL719 (two-thirds of the patients) or cetuximab alone (the remaining one-third of patients).