Head & Neck Cancers: Our Clinical Trials

Clinical trials are research studies that evaluate the safety and effectiveness of new treatment approaches for a disease. If you are being treated for a head and neck cancer, you may be offered the opportunity to take part in a clinical trial at some point during your treatment.

In some cases, a study may give you access to new therapies that are not yet readily available. Clinical trials may also be used to compare diagnostic tests, prevention strategies, or other aspects of your care.

If you are asked to participate in a clinical trial, your doctor or nurse will explain exactly what is involved and any possible benefits or drawbacks posed by the trial. They will explain to you that that unexpected side effects may occur if you enroll in a clinical trial. You will need to sign an informed consent agreement in order to participate in the trial. Before agreeing to participate, make sure you know what the costs will be and how much your insurance will cover.

You are not required to participate in clinical trials. If you decline, this will not jeopardize your relationship with your physician. You may leave a trial for any reason and at any time, even after signing the agreement.

Here you can find a continually updated listing of Memorial Sloan Kettering's current clinical trials for head and neck cancers. To learn more about a study, choose from the list below.

Showing 23 trials
Titlesort icon Investigator
Surviving Oropharynx Cancer: Long-Term Impact of Human Papillomavirus on Quality of Life
[Protocol 10-111]
Baxi, Shrujal, MD
Feasibility Study Using Fluoro-Misonidazole Positron Emission Tomography to Detect Hypoxia in Head and Neck Cancer Patients
[Protocol 04-070]
Lee, Nancy, MD
Development and Validation of a New Patient-Reported Outcome Instrument on the Impact of Altered Facial Appearance Following Oncologic Head and Neck Resection and Reconstruction
[Protocol 07-098]
Pusic, Andrea, MD, MHS
A Study of Customized Treatment for Nasopharyngeal Cancer Based on Epstein-Barr Virus DNA
Newly Diagnosed
[Protocol 14-162]
Lee, Nancy, MD
A Phase III Study of Postoperative Radiation Therapy with and without Cetuximab for Locally Advanced Resected Head and Neck Cancer
[Protocol 10-081]
Lee, Nancy, MD
A Phase III Study of Dapsone Gel versus Moisturizer (Placebo) to Treat Cetuximab-Related Rash
[Protocol 13-012]
Lacouture, Mario, MD
A Phase II/III Study of Surgery Followed by Radiation Therapy plus either Cisplatin, Docetaxel, or Both Drugs for High-Risk Squamous Cell Cancer of the Head and Neck
[Protocol 13-115]
Lee, Nancy, MD
A Phase II Study of Vismodegib plus Radiation Therapy for Locally Advanced Basal Cell Cancers of the Head and Neck
[Protocol 14-022]
Barker, Christopher, MD
A Phase II Study of Transoral Surgical Removal of HPV-Positive Locally Advanced Oropharynx Cancer Followed by Risk-Stratified Therapy
Relapsed/Refractory
[Protocol 14-035]
Morris, Luc, MD
A Phase II Study of Regorafenib in Patients with Recurrent or Metastatic Adenoid Cystic Carcinoma
[Protocol 13-244]
Ho, Alan, MD, PhD
A Phase II Study of Minimally Invasive Surgery Followed by Radiation and Chemotherapy versus Higher Dose Radiation and Chemotherapy for Patients with HPV-Negative Oropharynx Cancer
Relapsed/Refractory
[Protocol 14-038]
Ganly, Ian, MD, PhD
A Phase II Study of IZN-6N4 to Reduce Mouth Sores in Patients with Head and Neck Cancer Receiving Chemotherapy and Radiation Therapy
[Protocol 12-204]
Lee, Nancy, MD
A Phase II Study of Intensity-Modulated Radiation Therapy for the Treatment of Non-Anaplastic Non-Medullary Thyroid Cancer
[Protocol 13-070]
Lee, Nancy, MD
A Phase II Study of Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
[Protocol 11-005]
Lee, Nancy, MD
A Phase IB Study of Urelumab (BMS-663513) plus Cetuximab in Patients with Persistent Head and Neck or Colorectal Cancer
[Protocol 14-121]
Segal, Neil, MD, PhD
A Phase IB Study of INC280 plus Cetuximab in Patients with Recurrent or Metastatic Colorectal or Head and Neck Cancer
[Protocol 14-173]
Fury, Matthew, MD, PhD
A Phase I/II Study of BYL719 plus Cetuximab in Patients with Recurrent or Metastatic Head and Neck Cancer
[Protocol 14-021]
Fury, Matthew, MD, PhD
A Phase I Study of MEDI4736 in Patients with Advanced Solid Tumors
[Protocol 13-198]
Callahan, Margaret, MD, PhD
A Phase I Study of Lurbinectedin plus Paclitaxel in Patients with Advanced Solid Tumors
[Protocol 13-170]
Drilon, Alexander, MD
A Phase I Study of DLYE5953A in Patients with Advanced or Persistent Solid Tumors
[Protocol 14-089]
Modi, Shanu, MD
A Phase I Study of Debio1347 in Patients with Advanced Cancers Containing FGFR Alterations
[Protocol 13-131]
Voss, Martin, MD
A Phase I Study of CB-839 in Patients with Advanced Solid Tumors
[Protocol 14-111]
Harding, James, MD
A Phase I Study of BYL719 Given with Cetuximab and Radiation Therapy in Patients with Stage III/IVB Head and Neck Cancer
[Protocol 14-116]
Fury, Matthew, MD, PhD