MPDL3280A is an investigational drug designed to improve the immune system’s ability to recognize and destroy cancer cells by blocking PD-L1, a protein made by some cancers. In this study, researchers are evaluating the safety and effectiveness of giving MPDL3280A alone or in combination with bevacizumab in patients newly diagnosed with an advanced form of kidney cancer called renal cell carcinoma. Investigators are also comparing these two treatments with a third therapy, sunitinib, which is already used to treat renal cell cancer.
Patients in this study will be randomly assigned to receive one of these three treatments:
- MPDL3280A alone
- MPDL3280A with bevacizumab, which is also already used to treat renal cell cancer
- sunitinib alone
MPDL3280A and bevacizumab are each given intravenously (by vein). Sunitinib is a capsule that is taken orally (by mouth).