In this “Ask the Expert” feature, pediatrichematologist Andromachi Scaradavou discusses options for expectant parents who are considering banking a newborn’s cord blood.
Dr. Douer, leader of the research program in acutelymphoblasticleukemia, talks about how patients are treated by a caring team that includes physicians, nurses, social workers, and support staff.
Memorial Sloan-Kettering researchers have used genetically modified immune cells to eradicate cancer in five patients with acute lymphoblastic leukemia.
Medical oncologist Dr. Chung specializes in working with patients who have leukemia and bone marrow failure syndromes, from diagnosis through treatment and general medical care.
Scientists from Memorial Sloan-Kettering have collaborated on the discovery of a unique monoclonal antibody, called ESK1, that appears to be effective at targeting and destroying several types of cancer cells.
Chief of the Leukemia Service Dr. Tallman discusses how experts collaborate to deliver the most-promising therapies, and how he cares for patients as if they were members of his own family.
With the genomics revolution, scientists and physicians have increasingly been able to peer at the inner workings of tumor cells and pinpoint the specific genetic changes that transform them from their cells of origin into cancer.
Memorial Sloan-Kettering researchers have found why certain drugs are not sufficiently effective in treating leukemias called myeloproliferative neoplasms.
Adult Bone Marrow Transplantation Service Chief Sergio Giralt explains recent advances that are enabling more patients to survive the most difficult period after receiving a transplant.
Researchers have identified a set of genetic abnormalities that can enhance prognostic accuracy and aid treatment selection for people with acute myelogenous leukemia (AML).
Years of innovative research, technology development, and facility expansion at Memorial Sloan-Kettering have led to several new experimental treatments for people with cancer.
German-born cancer biologist Hans-Guido Wendel is taking advantage of transformative advances in genomics technology to understand key genetic abnormalities in leukemia and lymphoma.
A surprising discovery has been made about how the cancer drug imatinib (Gleevec ®) works in treating blood cancers and gastrointestinal stromal tumors.
A study led by researchers at Memorial Sloan-Kettering and New York University has shown that TET2 loss enhances the function of blood stem cells, causing them to renew themselves more efficiently than normal blood stem cells.
Martin S. Tallman, MD, has been appointed Chief of the Leukemia Service in the Department of Medicine at Memorial Sloan-Kettering Cancer Center and Professor of Medicine at the Weill Cornell Medical College.
A new study led by researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) reports on a novel mechanism that can enhance the function of a protein that is frequently impaired in patients with acute forms of leukemia.
Scientists have uncovered new information about what orchestrates the complex balance between blood stem cells and mature blood cells, a relationship that is often disrupted in leukemia. The results will lead to a better understanding of the behavior of leukemic cells and may have vitalclinical applications for patients recovering from chemotherapy, radiationtherapy, or bone marrow transplantation.
March 13, 2006
acute (uh-KYOOT)
Symptoms or signs that begin and worsen quickly; not chronic.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphocytic leukemia and ALL.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myeloid leukemia, acute nonlymphocytic leukemia, AML, and ANLL.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
antibody (AN-tee-BAH-dee)
A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
blood (blud)
A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
bone marrow (bone MAYR-oh)
The soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
bone marrow transplantation (bone MAYR-oh tranz-plan-TAY-shun)
A procedure to replace bone marrow that has been destroyed by treatment with high doses of anticancer drugs or radiation. Transplantation may be autologous (an individual's own marrow saved before treatment), allogeneic (marrow donated by someone else), or syngeneic (marrow donated by an identical twin).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
cancer (KAN-ser)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
chemotherapy (KEE-moh-THAYR-uh-pee)
Treatment with drugs that kill cancer cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
clinical (KLIH-nih-kul)
Having to do with the examination and treatment of patients.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
diagnosis (DY-ug-NOH-sis)
The process of identifying a disease, such as cancer, from its signs and symptoms.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
drug (drug)
Any substance, other than food, that is used to prevent, diagnose, treat or relieve symptoms of a disease or abnormal condition. Also refers to a substance that alters mood or body function, or that can be habit-forming or addictive, especially a narcotic.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
experimental (ek-SPAYR-ih-men-tul)
In clinical trials, refers to a drug (including a new drug, dose, combination, or route of administration) or procedure that has undergone basic laboratory testing and received approval from the U.S. Food and Drug Administration (FDA) to be tested in human subjects. A drug or procedure may be approved by the FDA for use in one disease or condition, but be considered experimental in other diseases or conditions. Also called investigational.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
gastrointestinal (GAS-troh-in-TES-tih-nul)
Refers to the stomach and intestines. Also called GI.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
genetic (jeh-NEH-tik)
Inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
genetic testing (jeh-NEH-tik TES-ting)
Analyzing DNA to look for a genetic alteration that may indicate an increased risk for developing a specific disease or disorder.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
genomics (jeh-NOH-mix)
The study of the complete genetic material, including genes and their functions, of an organism.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
hematologist (HEE-muh-TAH-loh-jist)
A doctor who specializes in treating blood disorders.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
leukemia (loo-KEE-mee-uh)
Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
lymphoblastic (LIM-foh-BLAS-tik)
Refers to lymphoblasts (a type of immature white blood cell).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
lymphoma (lim-FOH-muh)
Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
medical oncologist (MEH-dih-kul on-KAH-loh-jist)
A doctor who specializes in diagnosing and treating cancer using chemotherapy, hormonal therapy, biological therapy, and targeted therapy. A medical oncologist often is the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
medicine (MEH-dih-sin)
Refers to the practices and procedures used for the prevention, treatment, or relief of symptoms of a diseases or abnormal conditions. This term may also refer to a legal drug used for the same purpose.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
myelogenous (MY-eh-LAH-jeh-nus)
Having to do with, produced by, or resembling the bone marrow. Sometimes used as a synonym for myeloid; for example, acute myeloid leukemia and acute myelogenous leukemia are the same disease.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
pediatric (pee-dee-A-trik)
Having to do with children.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
protein (PROH-teen)
A molecule made up of amino acids that are needed for the body to function properly. Proteins are the basis of body structures such as skin and hair and of substances such as enzymes, cytokines, and antibodies.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
radiation (RAY-dee-AY-shun)
Energy released in the form of particle or electromagnetic waves. Common sources of radiation include radon gas, cosmic rays from outer space, medical x-rays, and energy given off by a radioisotope (unstable form of a chemical element that releases radiation as it breaks down and becomes more stable).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
therapy (THAYR-uh-pee)
Treatment.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
tissue (TIH-shoo)
A group or layer of cells that work together to perform a specific function.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
transplantation (tranz-plan-TAY-shun)
A surgical procedure in which tissue or an organ is transferred from one area of a person’s body to another area, or from one person (the donor) to another person (the recipient).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
tumor (TOO-mer)
An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
vital (VY-tul)
Necessary to maintain life. Breathing is a vital function.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
will (wil)
A legal document in which a person states what is to be done with his or her property after death, who is to carry out the terms of the will, and who is to care for any minor children.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)