The purpose of this study is to evaluate the combination of two approaches to delivering chemotherapy for liver tumors. One approach, hepatic arterial infusion, delivers chemotherapy directly to the liver through a small metal pump surgically implanted in the abdomen. The second approach is intravenous chemotherapy, which is given by vein.
In this study, researchers are evaluating hepatic arterial infusion with the drugs floxuridine and dexamethasone in combination with systemic treatment using gemcitabine and oxaliplatin in patients with a type of liver tumor called cholangiocarcinoma that cannot be surgically removed. They are also assessing a form of magnetic resonance imaging to measure the response of the tumor to treatment.