Etoposide and cisplatin are two chemotherapy drugs commonly used to treat small cell lung cancer (SCLC). However, many patients still succumb to the disease. In this study, researchers want to find the highest dose of an investigational drug called LDE225 that can be given safely with etoposide and cisplatin in patients with extensive SCLC.
LDE225 works by inhibiting a cell signaling pathway called the Hedgehog pathway, which may be important for the growth of SCLC. It is a pill that is taken orally (by mouth).