Most non-small cell lung cancers (NSCLC) treated with the standard therapy erlotinib (a drug used to treat cancers with a mutated form of the epidermal growth factor receptor, or EGFR) eventually come back or continue to grow despite this treatment. Researchers want to find out if adding the investigational drug MPDL3280A to erlotinib therapy might make treatment more effective.
One purpose of this study is to find the highest dose of MPDL3280A that can be given safely together with the standard dose of erlotinib in patients with advanced NSCLC that has not previously been treated with erlotinib or other EGFR inhibitors. A second goal is to assess the response to this combination.
MPDL3280A is designed to improve the immune system’s ability to recognize and destroy cancer cells by blocking PD-L1, a protein made by some cancers. MPDL3280A is given intravenously (by vein), while erlotinib is taken orally (by mouth).