Most non-small cell lung cancers (NSCLC) treated with the standard therapy erlotinib (a drug used to treat cancers with a mutated form of the epidermal growth factor receptor, or EGFR) eventually grow despite this treatment. In many patients, the resistance to EGFR inhibitors like erlotinib is due to a mutation called EGFR T790M.
In this study, researchers are evaluating the safety and effectiveness of an investigational drug called EGF816 in patients with NSCLC that contain the EGFR T790M mutation. EGF816 binds to mutated EGFR and prevents it from working. Doctors hope it will be effective in patients whose NSCLC has stopped responding to erlotinib or other EGFR inhibitors.
EGF816 is a pill that is taken orally (by mouth).