Lung Cancer: Our Clinical Trials

In addition to providing excellent care, Memorial Sloan Kettering is constantly working to improve treatment for lung cancer through clinical trials. Participating in a clinical trial may give you access to treatments that are not widely available, and may offer additional options if your cancer has returned after standard treatment. It’s also a way to make a contribution to the fight against cancer.

Our physicians lead a large number of clinical trials that test new drugs and drug combinations, surgical and radiation therapy techniques, innovative diagnostic technologies, and strategies for preserving quality of life during and after treatment.  

We are also conducting a number of clinical trials to test the effectiveness of molecular profiling in treating non-small cell lung cancer. If the molecular makeup of your tumor matches certain eligibility criteria, your doctor may offer you the opportunity to participate in a clinical trial.

Our experts can help to determine which clinical trials are right for you. The following clinical trials for lung cancer are currently enrolling new patients. To learn more about a particular study, choose from the list below. For more information about any of our clinical trials, call our physician referral service at 866-MSK-LUNG (866-675-5864), or talk with your doctor.

Learn more about clinical trials.

Showing 39 trials
Title Investigatorsort icon
A Phase I Study of AM0010 in Patients with Advanced Solid Tumors
[Protocol 13-224]
Autio, Karen, MD
A Phase I/II Study of Nivolumab Alone and with Ipilimumab in Patients with Advanced or Metastatic Solid Tumors
Relapsed/Refractory
[Protocol 13-187]
Callahan, Margaret, MD, PhD
A Phase I Study of MEDI4736 in Patients with Advanced Solid Tumors
[Protocol 13-198]
Callahan, Margaret, MD, PhD
A Phase II Study Comparing Three Months versus Two Years of Afatinib Therapy after Surgery for Patients with Stage I-III Non-Small Cell Lung Cancer
[Protocol 13-096]
Chaft, Jamie, MD
A Phase II Study of Neoadjuvant Pemetrexed Plus Cisplatin for Patients with Resectable Non-Squamous Non-Small Cell Lung Cancer with "Switch Chemotherapy Alternative" in Non-Responders (NEOSCAN)
[Protocol 11-106]
Chaft, Jamie, MD
A Phase II Study of MPDL3280A in Patients with PD-L1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
[Protocol 14-024]
Chaft, Jamie, MD
A Phase II Study of MPDL3280A in Patients with PD-L1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
[Protocol 13-084]
Chaft, Jamie, MD
A Pilot Study of a Breathing Training Exercise to Reduce Chronic Shortness of Breath
[Protocol 12-261]
Deng, Gary, MD, PhD
A Phase I Study of Lurbinectedin plus Paclitaxel in Patients with Advanced Solid Tumors
[Protocol 13-170]
Drilon, Alexander, MD
A Phase I Study of SNX-5422 in Patients with Advanced Lung Cancer
[Protocol 13-230]
Drilon, Alexander, MD
A Phase II Study of Cabozantinib in Patients with Advanced Non-Small Cell Lung Cancer
[Protocol 12-097]
Drilon, Alexander, MD
A Phase II Study Assessing PET/CT Scanning to Guide Radiation Treatment for Inoperable Stage III Non-Small Cell Lung Cancer
[Protocol 14-032]
Gelblum, Daphna, MD
A Phase I Study of MEDI3617 in Patients with Advanced Solid Tumors
[Protocol 11-052]
Hyman, David, MD
A Phase II Study of Neratinib Alone and with Temsirolimus in Patients with Non-Small Cell Lung Cancer with HER2 Mutations
[Protocol 13-087]
Kris, Mark, MD
A Phase I Study of DLYE5953A in Patients with Advanced or Persistent Solid Tumors
[Protocol 14-089]
Modi, Shanu, MD
A Psychometric Assessment of the Stigma Associated with Lung Cancer
[Protocol 14-012]
Ostroff, Jamie, PhD
A Phase II Study of Dasatinib in Patients with Advanced Non-Small Cell Lung Cancers with DDR2 or Inactivating BRAF Mutations
[Protocol 12-163]
Paik, Paul, MD
A Phase I/II Study of SC16LD6.5 in Patients with Recurrent Small Cell Lung Cancer
[Protocol 13-184]
Pietanza, M. Catherine, MD
A Phase I Study of LDE225 with Etoposide and Cisplatin for the Initial Treatment of Extensive Small Cell Lung Cancer
[Protocol 11-206]
Pietanza, M. Catherine, MD
A Phase II Study of Temozolomide Alone or with ABT-888 (Veliparib) in Patients with Relapsed or Refractory Small Cell Lung Cancer
[Protocol 12-021]
Pietanza, M. Catherine, MD
A Phase III Study of Etoposide/Platinum with and without Ipilimumab in Patients with Newly Diagnosed Advanced Small Cell Lung Cancer
[Protocol 12-202]
Pietanza, M. Catherine, MD
A Phase IB/II Study of IPI-504 plus Everolimus in Patients with KRAS-Mutant Non-Small Cell Lung Cancer
[Protocol 11-114]
Riely, Gregory, MD, PhD
A Phase I/II Study of Crizotinib and Ganetespib (STA-9090) in ALK-Positive Lung Cancers
[Protocol 12-015]
Riely, Gregory, MD, PhD
A Phase II Study of Bortezomib in Patients with KRAS-Mutant Non-Small Cell Lung Cancer
[Protocol 12-222]
Riely, Gregory, MD, PhD
A Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide
[Protocol 11-003]
Rimner, Andreas, MD
A Study Assessing the Predictive Value of Tumor Hypoxia (Low Oxygen Supply) in Patients with Non-Small Cell Lung Cancer
[Protocol 13-186]
Rimner, Andreas, MD
Calypso-Based Deep Inspiration Breath Hold Radiation Treatment for Lung Cancer
[Protocol 13-174]
Rimner, Andreas, MD
A Phase I Study of Stereotactic Body Radiation Therapy for Inoperable Locally Advanced Non-Small Cell Lung Cancer
Newly Diagnosed
[Protocol 13-113]
Rimner, Andreas, MD
A Phase Ib Study of Tremelimumab and MEDI4736 in Patients with Advanced Non-Small Cell Lung Cancer
[Protocol 13-197]
Rizvi, Naiyer, MD
A Phase I Study of Nivolumab with Combination Chemotherapy for Patients with Previously Untreated Stage IIIB or IV Non-Small Cell Lung Cancer
[Protocol 11-189]
Rizvi, Naiyer, MD
A Phase I Study of BMS-986015 with Ipilimumab in Patients with Advanced Non-Small Cell Lung Cancer, Prostate Cancer, or Melanoma
[Protocol 12-283]
Rizvi, Naiyer, MD
A Phase IB Study of MPDL3280A and Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer
[Protocol 14-020]
Rudin, Charles, MD, PhD
A Phase I Study of GL-ONC1 for Treating Malignant Pleural Effusion
[Protocol 12-169]
Rusch, Valerie, MD
A Phase I Study of MEDI4736 in Patients with Advanced Solid Tumors
[Protocol 12-179]
Segal, Neil, MD, PhD
A Phase I Study of Lirilumab plus Nivolumab in Patients with Advanced Solid Tumors
[Protocol 12-224]
Segal, Neil, MD, PhD
A Phase I Study of Debio1347 in Patients with Advanced Cancers Containing FGFR Alterations
[Protocol 13-131]
Voss, Martin, MD
A Phase II Study of SNX-5422 in Patients with Select Advanced HER2 Cancers
[Protocol 13-112]
Voss, Martin, MD
A Phase II Study of Intermittent Dacomitinib in Patients with Advanced Non-Small Cell Lung Cancer
[Protocol 13-036]
Yu, Helena, MD
A Phase I Study of Daily Low-Dose Erlotinib and Twice Weekly High-Dose Erlotinib in Patients with EGFR-Mutant Non-Small Cell Lung Cancer
[Protocol 12-278]
Yu, Helena, MD