Neurotropic melanoma is melanoma that develops in or around nerves. It has a high risk of returning in the same area. When this type of melanoma develops in the head and neck area, the standard therapy is surgery. In some hospitals, radiation therapy is given soon after surgery to reduce the risk of cancer recurrence, but this care is not yet standard. It is not yet known if the benefits of immediate radiation therapy after surgery outweigh the risks.
In this study, researchers are comparing surgery followed by radiation therapy with surgery alone in patients with neurotropic melanoma of the head and neck. Patients will be randomly assigned to receive surgery followed by four weeks of radiation therapy to the area where the surgery was performed, or observation without radiation therapy. Patients in the observation group who experience a return of their melanoma can receive radiation therapy at that point.