The p53 protein normally acts to control cell growth. Many tumor cells find ways to prevent p53 from working, however. HDM201 is an investigational drug that may restore normal function to the p53 protein, causing tumor cells to weaken or die. In order for the drug to work, patients must have a normal (“wild-type”) version of the gene that governs the production of p53, called TP53.
The purpose of this study is to find the highest dose of HDM201 that can be given safely in patients with advanced solid tumors and blood cancers and normal TP53. HDM201 is taken orally (by mouth).