Fibroblast growth factor receptor 1 (FGFR1) can cause cancers to grow and divide. FGFs are a group of proteins that turn on FGFR1. GSK3052230 is an investigational drug that traps FGFs and prevents them from turning on FGFR1. Laboratory studies have shown that GSK3052230 can prevent tumors from growing, and that this effect may be greater when the drug is given in combination with chemotherapy.
In this study, researchers want to find the highest dose of GSK3052230 that can be given safely with chemotherapy in patients with squamous cell lung cancers that have spread and have high levels of FGFR1. They will also study the safety of GSK3052230 plus chemotherapy in patients with advanced malignant pleural mesothelioma. Patients will be assigned to one of three groups:
- GSK3052230 with carboplatin and paclitaxel for patients with untreated stage IV squamous cell lung cancers
- GSK3052230 with docetaxel for patients with stage IV squamous cell lung cancers that continued to grow despite first-line (initial) treatment
- GSK3052230 with cisplatin and pemetrexed for patients with untreated advanced malignant pleural mesothelioma
GSK3052230 is given intravenously (by vein).