Myelodysplastic Syndrome: Our Clinical Trials

Receiving treatment in a clinical trial should be carefully considered, and your Memorial Sloan-Kettering MDS physician will help you to decide if such a treatment is right for you. Before you enroll in a clinical trial, you may wish to consider the following:

  • A number of eligibility criteria will need to be met, which relate to your disease and your general health. To determine your eligibility for a clinical trial, additional blood tests and sometimes bone marrow tests are needed. Other tests, such as an electrocardiogram, or EKG (a test of heart function), may also be performed.
  • Involvement in clinical trials usually involves multiple trips to Memorial Sloan-Kettering to receive the new treatment, to undergo extra tests to learn more about the new treatment, or to monitor for side effects.
  • New treatments being tested in trials have not yet been proven to be better than standard treatments such as 5-azacytidine, decitabine, and lenalidomide.
  • If you have already received standard treatments, then clinical trials may be an option to consider in addition to receiving supportive care.
  • Every clinical trial is different and your MDS physician can help you to determine which trial may be the best for you.
  • Sometimes, clinical trials should be considered as the first treatment. Please discuss this with your MDS physician to see if this is the right choice for you.

Here you can find a continually updated listing of Memorial Sloan-Kettering’s current clinical trials for adults with myelodysplastic syndrome (MDS). To learn more about a study, choose from the list below.

Showing 15 trials
Titlesort icon Investigator
A Phase I Study of WT1-Sensitized T cells for Residual or Relapsed Leukemia after Allogeneic Hematopoietic Progenitor Cell Transplantation
[Protocol 07-055]
O'Reilly, Richard, MD
A Phase I/II Study of Decitabine and All-Trans Retinoic Acid (Tretinoin) for Patients with Myelodysplastic Syndromes
[Protocol 06-054]
Klimek, Virginia, MD
A Phase I/II Trial of Clofarabine, Melphalan, and Thiotepa Followed by an Allogeneic Stem Cell Transplant for the Treatment of High-Risk and/or Advanced Hematologic Malignancies
[Protocol 06-125]
Boulad, Farid, MD
A Phase II Pilot Trial of Hematopoietic Stem Cell Transplantation with Total Body Irradiation, Cyclophosphamide & Fludarabine to Treat Patients with Fanconi Anemia Lacking a Genotypically Identical Donor
[Protocol 01-062]
Boulad, Farid, MD
A Phase II Study of Maitake Mushroom Extract in Patients with Low-Risk, Untreated Myelodysplastic Syndrome
[Protocol 09-094]
Wesa, Kathleen, MD
A Phase II Study of Peri-transplant Palifermin followed by an Allogeneic T-Cell-Depleted Stem Cell Transplant in Patients with Advanced Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Evolved from MDS
[Protocol 08-008]
Castro-Malaspina, Hugo, MD
A Phase II Trial of Hematopoietic Stem Cell Transplantation for the Treatment of Patients with Fanconi Anemia
[Protocol 08-031]
Boulad, Farid, MD
A Phase II Trial of HLA Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Leukemia Following Allogeneic Hematopoietic Stem Cell Transplant
[Protocol 07-035]
Hsu, Katharine, MD, PhD
A Phase II Trial of Transplants from HLA-Compatible Donors with T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System for the Treatment of Patients with Hematologic Malignancies and Disorders
[Protocol 10-050]
O'Reilly, Richard, MD
A Phase III Study of Lenalidomide Alone and in Combination with Epoetin Alfa in Patients with Myelodysplastic Syndromes and Symptomatic Anemia
[Protocol 10-128]
Klimek, Virginia, MD
A Phase III Study of Pomalidomide versus Placebo in Patients with Myeloproliferative Neoplasm-Associated Myelofibrosis Who Are Dependent on Red Blood Cell Transfusions
[Protocol 11-025]
Heaney, Mark, MD, PhD
A Reduced Intensity Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients with Acute Leukemia or Myelodysplasia
[Protocol 08-087]
Barker, Juliet, MBBS
A Study of Posaconazole Versus Micafungin to Protect Against Invasive Fungal Infections in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia or Myelodysplastic Syndrome
[Protocol 10-038]
Papanicolaou, Genovefa, MD
Cyclophosphamide, Fludarabine, and Total Body Irradiation Followed by the Transplantation of Unrelated Double-Unit Donor Umbilical Cord Blood Grafts for Patients with Hematological Malignancy
[Protocol 06-014]
Barker, Juliet, MBBS
Phase I Study of Actinium-225-Labeled HuM195 Antibody in Patients with Advanced Myeloid Malignancies
[Protocol 02-017]
Jurcic, Joseph, MD