The purpose of this Gynecologic Oncology Group study is to evaluate the safety and effectiveness of various dosing regimens of an investigational drug called ABT-888 when given with carboplatin, paclitaxel, and bevacizumab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer who have not had chemotherapy.
ABT-888 kills cancer cells by preventing the repair of DNA or genetic damage in cancer cells, possibly making them more susceptible to anticancer drugs. It can also work well in cancer cells that do not have functional BRCA, a protein which helps to fix DNA damage. About 10 percent of ovarian cancer patients have an inherited defect in BRCA.
Carboplatin and paclitaxel are used routinely to treat these cancers. Bevacizumab is approved for the treatment of other cancers; its use in these cancers is considered investigational.