Gemcitabine is a chemotherapy drug commonly used to treat pancreatic cancer. However, more effective treatments are greatly needed. In this study, researchers want to find the highest dose of an investigational drug called LDE225 that can be given safely with gemcitabine in patients with locally advanced or metastatic pancreatic cancer.
LDE225 works by inhibiting a cell signaling pathway called the Hedgehog pathway, which may be important for the growth of pancreatic cancer. It is a pill that is taken orally (by mouth).