Glutaminase is an enzyme that makes energy for cancer cells and for the body. CB-839 is an investigational drug designed to block glutaminase. Laboratory studies have shown that it can stop cancer cells from growing, but it does not harm normal cells.
In this study, researchers want to find the highest dose of CB-839 that can be given safely in patients with advanced solid tumors that have continued to grow despite standard therapy or for which no standard therapy exists. CB-839 is taken orally (by mouth).