This phase I study will evaluate the safety and effectiveness of different doses of a patient’s own immune cells (T cells) which have been changed to help recognize and destroy his prostate cancer cells by targeting a protein called prostate-specific membrane antigen. The T cells are removed from the patient’s blood, modified with a gene in the laboratory so they are better able to recognize and kill prostate cancer cells, and then returned to the patient’s body. This gene is inserted into the T cells using a weakened virus. /
It is hoped that this approach will help each patient’s own T cells recognize his prostate cancer cells and possibly kill them.