Armodafinil (Nuvigil) is a drug that activates parts of the brain which maintain a state of wakefulness and alertness. It is used to treat people with sleep disorders as well as people who have fatigue as a result of neurologic problems.
In this study, researchers want to know if armodafinil is useful for treating cancer-related fatigue in patients with a type of brain tumor called high-grade glioma. Examples of high-grade gliomas include glioblastoma, anaplastic astrocytoma, and anaplastic oligodendroglioma. Patients will be randomly assigned to receive 150 mg of armodafinil per day, 250 mg of armodafinil per day, or a placebo (sugar pill) for eight weeks. Armodafinil is taken orally (by mouth).
Patients will complete questionnaires about their cancer-related fatigue and also take memory and concentration skills tests.