SAR405838 is an investigational anticancer drug that inhibits a protein called MDM2, which may help tumor cells survive and grow. The purpose of this study is to find the highest dose of SAR405838 that can be given safely in patients with liposarcoma and other advanced cancers that have either continued to grow despite standard therapy or for which no standard treatments exist. SAR405838 is a capsule that is taken orally (by mouth).
While this study will include patients with many types of advanced cancer, researchers are particularly interested in seeing how active SAR405838 is against liposarcoma, a type of cancer that has very high levels of MDM2. Because of this, more spots in the study are reserved for patients with liposarcoma than for other types of cancer.