In some young cancer patients, cancer seemingly occurs spontaneously without any known risk factors or family history. This study will look for new types of gene changes (mutations) that may be related to cancer in some young patients. Some mutations are passed on from parents to a child (offspring). Others are new and are seen for the first time in the offspring, but not in the parent. Some of these new mutations may cause cancers in the offspring.
In this study, researchers are seeking to identify new mutations related to cancer by studying both patients with cancer as well as their parents who don’t have cancer. Participants will complete a medical and family history questionnaire and also give a saliva or blood sample to be used for genetic analysis. Afterwards, the participant’s parents will also be asked to provide a saliva sample.