Treatment with the chemotherapy drugs bleomycin, etoposide, and cisplatin is the standard therapy for newly diagnosed advanced-stage germ cell tumors, but it does not cure every patient. Paclitaxel, ifosfamide, and cisplatin are anticancer drugs used together to treat patients whose tumors have returned following bleomycin/etoposide/cisplatin. Prior clinical studies have shown that using paclitaxel/ifosfamide/cisplatin as the initial treatment in patients with advanced germ cell cancers may be more effective than the standard therapy.
In this study, researchers want to compare these two treatment regimens in patients with previously untreated advanced germ cell tumors. Patients will be randomly assigned to receive paclitaxel/ifosfamide/cisplatin or bleomycin/etoposide/cisplatin as initial therapy. All of these drugs are approved for treating various types of cancer.