Chemotherapy plus radiation therapy to the neck is the standard treatment for anaplastic thyroid cancer. The purpose of this study is to evaluate the safety and effectiveness of adding pazopanib to chemoradiation (radiation plus the drug paclitaxel) in patients with anaplastic thyroid cancer.
Pazopanib is a drug that has been approved to treat advanced kidney cancer; however, its use in anaplastic thyroid cancer is considered investigational. Pazopanib interferes with cell growth and reduces the growth of new blood vessels. It may delay the growth of tumor cells.
Paclitaxel is a chemotherapy drug that has been shown to have activity against anaplastic thyroid cancer. Pazopanib give alone has had antitumor effects on anaplastic cancer cells in the laboratory, and when used together with paclitaxel, it has enhanced antitumor activity against other cancer cells.
In this study, patients will be randomly assigned to receive paclitaxel and radiation with pazopanib or a placebo.