I am a physician-scientist with a special expertise in cancer immunology, the study of the immune system and cancer. I also have a particular focus on understanding and treating melanoma, and I have developed novel treatments for this deadly form of skin cancer.
My research is focused on understanding both how the immune system recognizes cancer and how it rejects cancer. My colleagues and I conducted a clinical trial that was the first to show that a monoclonal antibody could significantly shrink a solid tumor — in this case melanoma. Additional studies in my laboratory have identified molecules and molecular targets on cancer cells that may be useful for therapy and many of these are being evaluated in clinical trials. These trials are investigating glycolipids, peptides, and DNA. The vaccines are being evaluated in people with metastatic melanoma, prostate, breast, pancreatic, and small-cell lung cancers, soft tissue sarcoma, and other cancers.