I am an Attending Physician at Memorial Sloan Kettering, Professor of Surgery at Weill-Cornell Medical College, and Director of Memorial Sloan Kettering’s new David M. Rubenstein Center for Pancreatic Cancer Research. Prior to this I was Professor of Surgery, Oncology and Cell Biology, and the Paul K. Neumann Professor in Pancreatic Cancer at Johns Hopkins.
My lab has a long track record of research productivity in the field of pancreatic cancer biology, and is known for establishing important links between pancreatic development and pancreatic cancer. These include the discovery of abnormal Notch pathway activation as an important driver of pancreatic tumorigenesis, development of the first zebrafish model of pancreatic cancer, identification of adult acinar cells as effective cells of origin for the initiation of pancreatic “ductal” neoplasia, and the recent discovery of a new stem cell associated with the earliest pre-invasive stages of the disease. Together with our extensive additional studies of pancreatic development and pancreatic epithelial plasticity, work from my group has generated important new insights regarding early events in human pancreatic cancer, including the likelihood that pancreatic ductal adenocarcinoma will arise from non-ductal cells of origin.