For Healthcare Professionals: Clinical Updates in Melanoma

Memorial Sloan-Kettering’s multidisciplinary team treats approximately 1,000 individuals newly diagnosed with melanoma annually. Members meet weekly to review cases and devise customized treatment plans. The team includes experts in the diagnosis and treatment of cutaneous and ocular melanoma, and also provides psychosocial support to melanoma patients and their caregivers.

We have special expertise in the treatment of metastatic melanoma, and our center is home to a vigorous basic science research program aimed at deciphering the molecular underpinnings of the disease. Many Memorial Sloan-Kettering patients have the opportunity to participate in clinical trials of novel therapies, and our scientists have made headway in identifying ways to harness the power of the immune system to treat the illness. Among other activities, our research teams were instrumental in the development and clinical testing of vemurafenib (Zelboraf®) and ipilimumab (YervoyTM), the first agents in more than a decade found to improve survival in advanced melanoma.

Combining Immunotherapy with Isolated Limb Infusion in Treating Advanced Melanoma

Surgical oncologist Charlotte Ariyan explains the standard treatment strategy for patients diagnosed with early melanoma, which can include surgical removal of the cancer.
 
Dr. Ariyan explains how she is leading a clinical trial with surgical oncologist Mary Sue Brady of a new treatment approach for patients with advanced disease, which combines chemotherapy and an immune system drug therapy. First, patients receive chemotherapy to an affected limb through a minimally invasive procedure known as an isolated limb infusion. Next, they receive a US Food and Drug Administration–approved immunotherapy treatment called ipilimumab (Yervoy ™).
 
Learn more about this clinical trial.