Controlled Amino Acid Therapy
Controlled Amino Acid Therapy (CAAT) was developed by Angelo P John of the A. P. John Institute for Cancer Research. It is an amino acid and carbohydrate deprivation protocol. The objective of the therapy is to impair the development of cancer cells by altering cell formation through structure, energy, blood vessels, growth hormones and cell functions. The regimen consists of a carbohydrate and protein restricted diet with added supplements. In addition, supplementation with Superoxide Dismutase, curcumin, parsley, quercetin, lycopene, Vitamin D and green tea extract is encouraged. (See individual monographs for more information about those supplements.) The protocol is meant to be maintained for six to nine months as an adjunct to conventional chemotherapy and radiation (1). Whereas the Institute's website describes studies that support the theories behind the protocol, no studies have been conducted to determine the safety or efficacy of the regimen itself.
Proprietary amino-acid deprivation formula (1)
Mechanism of Action
According to the proponents, CAAT curbs the growth of cancer cells by impairing a number of factors essential to their growth. Restricting the cancer cell's access to glycine is thought to limit its ability to replicate its DNA, build new blood vessels, and create growth factors and other hormones essential for metastatic growth. Additionally, the low-carbohydrate diet is supposed to inhibit glycolysis, the main mechanism for cancer cells to derive energy (1).
Literature Summary and Critique
There are no studies to support use of CAAT for cancer.