Health Care Professional Information
Common Name
Dawn Dewa, Leaves of the Gods, Googoolipid, Mollucan spinach
Clinical Summary
Native to Nepal, cholesterol spinach is a hardy, fast-growing plant and is related to Okinawan spinach. It has gained popularity in Hawaii based on the anecdotal evidence of its cholesterol-lowering effects (1).
A plant of the same genus as cholesterol spinach lowered cholesterol and triglyceride levels in diabetic rats (2), but cholesterol spinach has not been studied so far.
Mechanism of Action
An extract of a related species, Gynura procumbens, reduced serum cholesterol and triglyceride levels in diabetic rats. G. procumbens did not affect cytochrome P450 activity. Whether the effects or mechanism of action of G. procumbens are similar to G. nepalensis has not been determined.
(2)
Contraindications
Immunocompromised patients should be cautioned when consuming raw vegetables due to possible contamination.
(3)
Consumer Information
How It Works
Bottom Line: Despite the anecdotes from Hawaii about this plant being able to lower cholesterol, there is no scientific evidence that it works.
Cholesterol spinach (also known as dawn dewa, Mollucan spinach) is a plant originally cultivated in Nepal that has received much attention lately for its use in Hawaii as a cholesterol-lowering nutritional supplement. Despite the excitement over this plant, there is no scientific evidence that explains why it might work to lower cholesterol. It has not been tested in animals, but a related species of plant was found to reduce blood levels of cholesterol and triglycerides when fed to rats with diabetes. However, scientists are not sure that this related species would have the same biological effects as cholesterol spinach, so these results cannot really be applied to what effects cholesterol spinach might have in the human body.
Purported Uses
- To lower high cholesterol
No scientific evidence supports this use.
Research Evidence
No laboratory, animal, or clinical research has been performed with this plant to test the anecdotal claims of its cholesterol-lowering potential.
Do Not Take If
- You have a weakened immune system due to chemotherapy, HIV infection, immuno-suppressant drugs, or any other causes (there is a potential for raw vegetables to be contaminated with bacteria, fungi, or other pathogens.)
Last updated: May 9, 2011
bacteria (bak-TEER-ee-uh)
A large group of single-cell microorganisms. Some cause infections and disease in animals and humans. The singular of bacteria is bacterium.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
biological (BY-oh-LAH-jih-kul)
Pertaining to biology or to life and living things. In medicine, refers to a substance made from a living organism or its products. Biologicals may be used to prevent, diagnose, treat or relieve of symptoms of a disease. For example, antibodies, interleukins, and vaccines are biologicals. Biological also refers to parents and children who are related by blood.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
blood (blud)
A tissue with red blood cells, white blood cells, platelets, and other substances suspended in fluid called plasma. Blood takes oxygen and nutrients to the tissues, and carries away wastes.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
cholesterol (koh-LES-teh-rol)
A waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid. Cholesterol also comes from eating foods taken from animals such as egg yolks, meat, and whole-milk dairy products. Too much cholesterol in the blood may build up in blood vessel walls, block blood flow to tissues and organs, and increase the risk of developing heart disease and stroke.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
clinical (KLIH-nih-kul)
Having to do with the examination and treatment of patients.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
diabetes (dy-uh-BEE-teez)
Any of several diseases in which the kidneys make a large amount of urine. Diabetes usually refers to diabetes mellitus in which there is also a high level of glucose (a type of sugar) in the blood because the body does not make enough insulin or use it the way it should.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
extract (EK-strakt)
In medicine, a preparation of a substance obtained from plants, animals, or bacteria and used as a drug or in drugs.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
nutritional supplement (noo-TRIH-shuh-nul SUH-pleh-ment)
A product that is added to the diet. A nutritional supplement is taken by mouth, and usually contains one or more dietary ingredient (such as vitamin, mineral, herb, amino acid, and enzyme). Also called dietary supplement.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)
serum (SEER-um)
The clear liquid part of the blood that remains after blood cells and clotting proteins have been removed.
Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)