Reported (DBM): Increased pain at tumor site in advanced cancer patients; somnolence, diarrhea, nausea, vomiting, anorexia, grade I hyperglycemia, ankle-feet edema; anemia and thrombocytopenia were noted in trials using cyclophosphamide (12).
Case Report (DBM): A breast cancer patient with lung and liver metastases developed acute myeloid leukemia, which her physicians associate with chronic cyclophosphamide use, after treatment with Di Bella therapy. Her leukemia led rapidly to death due to cerebral hemorrhage (13).
Common (Somatostatin): Gastrointestinal complaints (diarrhea, vomiting, and nausea), cholelithiasis, and effects on glucose metabolism (6).
Toxicity (Somatostatin): Pain at injection site, allergic reactions, hair loss, a few cases of reversible hepatic dysfunction (11).
Reported (Bromocriptine): Hypotension, peripheral vasoconstriction, dyskinesias, fatigue, nausea, vomiting, postpartum MI, headache, dizziness, psychosis (6).
Reported (Melatonin): Drowsiness, alterations in sleep patterns, altered mental status, disorientation, tachycardia, flushing, pruritus, abdominal cramps, headache, hypothermia (6) (8) (14) (15).