Fifty-five individuals with high cholesterol were given flaxseed-derived lignan extracts (300 or 600 mg/day) or placebo for 8 weeks after which fasting blood glucose levels and lipid profiles were tested. Subjects who received 600 mg of extract had reductions in total cholesterol, low density lipoprotein (LDL or bad cholesterol), and fasting blood glucose levels.
For this study, 68 type II diabetic participants received lignan supplements (360 mg/day) or placebo for 12 weeks. Subjects then underwent an 8-week washout period before receiving placebo. Glycemic control was modestly affected by lignan supplementation; however, there was no change in fasting glucose and insulin levels, insulin resistance, and blood lipid concentrations. Because the influence of lignan on glycemic control was modest, more studies are needed.
In this study, 46 postmenopausal women were received a placebo, soy (25 g soy flour), or flaxseed (25 g ground flaxseed) muffin for 16 weeks. Blood and 24-hour urine samples were checked for estrogen metabolites, serum hormones, and biochemical markers of bone metabolism. Results showed that the urinary concentrations of 2-hydroxyestrone, but not of 16alpha-hydroxyestrone increased significantly in the flaxseed group. But there was no effect on the biochemical markers of bone metabolism.