Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. Lipids in health and disease. 2009;8:7.
This is a double-blind study on the effects of African mango seed extract, IGOB131, based on metabolic parameters. One hundred and two overweight and obese subjects were randomly divided into the placebo group (50 subjects) and the IGOB131 group (52 subjects). The IGOB131 capsules were given orally, 30 to 60 minutes before lunch and dinner. At the end of the 10-week study, the seed extract group showed a greater decrease in body weight, waist circumference, body fat, total cholesterol, total LDL, C-reactive proteins, blood glucose, adiponectin, and leptin. Side effects were reported in both groups which included gas, headache, and sleep difficulty. These results would need to be replicated in larger independent clinical trials before this product can be recommended as a weight loss treatment.
Ngondi JL, Oben JE, Minka SR. The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon Lipids in health and disease. 2005;4:12.
Forty obese patients were enrolled in the trial, of whom 28 received African mango extract and 12 were given a placebo. The 350 mg capsules were taken for 4 weeks, 3 times a day, 30minutes before eating. At the end of the study, the seed extract group had a greater decrease in body weight and total cholesterol levels, with an increase in HDL cholesterol levels. However, this is a small study. Also, all subjects were instructed to eat low fat diet of 1800 Kcal. It is unclear if the weight loss was due to the diet or the African mango extract.