Lipovac M, Chedraui P, Gruenhut C, et al. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Gynecol Endocrinol. 2012 Mar;28(3):203-7.
In this study, 109 postmenopausal women aged 40 or more were randomized to receive two daily capsules of the active compound (80 mg red clover isoflavones, Group A) or a placebo (Group B) for 90 days. Following a washout period of 7 days, the medication and placebo was crossed over and administered for 90 more days. The frequency of daily hot flushes and night sweats, and overall menopausal symptom intensity (Kupperman Index) were measured at baseline, 90, 97 and 187 days. Researchers report that the KI values were similar in both studied groups at baseline, but decreased significantly after red clover treatment in Group A. And after washout and placebo phases, there was a significant rise in the values. In Group B, all indices remained the same after placebo and washout phases, but decreased significantly after red clover treatment. No side effects were reported with red clover.
Supplementation with red clover isoflavones may help to reduce vasomotor symptoms and overall menopausal intensity in postmenopausal women.
Tice J, et al. Phytoestrogen Supplements for the Treatment of Hot Flashes: The Isoflavone Clover Extract (ICE) Study: A Randomized Controlled Trial. JAMA 2003 Jul 9;290(2):207-14.
This was a large, multicenter, randomized, placebo-controlled trial of red clover extract involving 252 postmenopausal women. The participants were randomly assigned to take isoflavone clover extract from Promensil ®, Rimostil ® or an identical placebo daily for 12 weeks. Promensil ®, but not Rimonstil ®, was shown to reduce hot flashes at a faster rate than placebo during this period. However, the reduction of hot flashes after 12 weeks was similar in all three groups. The authors concluded that even though Promensil ® has biological effect, it does not have a significant effect on menopausal symptoms including hot flashes.