Health Care Professional Information

Clinical Summary

Yoga was first described in Vedic texts of India and has been practiced over the centuries. It is an integral part of Ayurveda, the traditional healing system that originated in India. The major components of yoga are regulated breathing, moving through various postures, and meditation, aimed at achieving physical and emotional health benefits, with self-realization being the ultimate goal. There are many styles of yoga that encompass some or all of these components. In the United States, most practices focus on postures, meditation, and breath control (1).

Yoga has been shown in preliminary studies to effectively reduce symptoms of carpal tunnel syndrome (2), irritable bowel syndrome (3), asthma (4), drug-resistant epilepsy (5), and for weight maintenance(6), diabetes (7) migraine (8), AIDS (9) and depression (10). Further well designed clinical trials are needed to confirm these effects. A systematic review did not find yoga an effective intervention for anxiety (11). However, preliminary findings from another study show that yoga may help relieve anxiety by increasing the levels of a neurotransmitter GABA (12). Analysis of a systematic review indicates that yoga is helpful in alleviating low back pain (13). Yoga can improve symptoms and quality of life in patients with paroxysmal atrial fibrillation (33).

With the introduction of yoga in many cancer centers across the country, patients now practice yoga for relief of symptoms and preliminary data are encouraging (14) (15). Studies in breast cancer survivors indicate that yoga has physical and psychological benefits by improving social functioning (16), improving mood, and reducing stress levels (17); reduction in number of hot flashes, fatigue (18), joint pain was associated with a yoga program in early-stage breast cancer survivors and the benefits persisted at the 3-month follow-up (19). In another study, practice of Tibetan yoga, which incorporates controlled breathing, visualization, mindfulness techniques, and low-impact postures, improved sleep quality in patients with lymphoma (20). Yoga also reduced stress, increased a sense of well-being, and resulted in more restful sleep in both newly diagnosed cancer patients and survivors (21) (22) (23). An eight-week mindfulness-based stress reduction program involving relaxation, meditation, and gentle yoga was shown to significantly improve symptoms of stress and overall quality of life in breast and prostate cancer outpatients (24). A meta-analysis of nine studies of cancer patients concluded that yoga may be an effective intervention for improving quality of life of cancer patients (1).

Adverse effects associated with improper Yoga practice have been reported. These include hematoma (25) (10), nerve damages (26), aggravation of glaucoma (27) (28), embolism (29), ligament rupture (30), and spontaneous pneumothorax (31) (32). Cancer patients interested in beginning yoga should first consult their physicians. Because of limitations due to surgery, chemotherapy, and radiotherapy, it is advisable to learn the proper technique from certified instructors who have experience working with cancer patients.

Purported Uses
  • Improvement of sleep quality
  • Stress
  • Pain
  • Depression
  • Flexibility and strength development
Mechanism of Action

Yoga is believed to benefit physical, mental, and spiritual health but the exact mechanism of action is not known. Yoga may increase the levels of a neurotransmitter GABA (12). Some studies have shown that meditation, a key component of yoga, increased blood flow to the brain, increased the release of endogenous dopamine, and reduced respiratory rate (5).

Contraindications

Pregnant women and individuals with hypertension or glaucoma should use caution when practicing certain yoga postures.

Adverse Reactions

Although adverse effects are rare, improper practice can cause hematoma (25) (10), nerve damage (26), aggravation of glaucoma (27) (28), embolism (29), ligament rupture (30), and pneumothorax (31) (32).

Literature Summary and Critique

Bower JE, Garet D, Sternlieb B, et al. Yoga for persistent fatigue in breast cancer survivors: A randomized controlled trial.Cancer. 2011 Dec 16.
This is a randomized controlled trial to study the effect of an Iyengar yoga in breast cancer survivors with persistent fatigue. Thirty-one women were randomly assigned to practice yoga for 12-week or to health education as control. Fatigue severity declined significantly from baseline in the yoga group as compared to the controls. The yoga group also had significant increases in vigor. There were no significant improvement in depressive symptoms, stress, sleep, and physical performance.

Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer 2004;100(10):2253-60.
This study involved 39 patients receiving chemotherapy or who completed treatment in the previous 12 months. They were randomized to Tibetan yoga or control groups. The Tibetan yoga was a seven-week program encompassing controlled breathing, visualization, and mindfulness. Outcomes assessed included distress, anxiety, depression, fatigue, and sleep disturbances. Participants in the Tibetan yoga group reported enhanced sleep quality, increased sleep duration, and less use of sleep medications compared to those in the control group. Studies with larger sample size are needed to confirm these observations.

Rosenbaum E, Gautier H, Fobair P, et al. Cancer supportive care, improving the quality of life for cancer patients. A program evaluation report. Supportive Care Cancer 2004;12(5):293-301.
The Stanford Cancer Supportive Care Program (SCSCP) was initiated in 1999 at the Center for Integrative Medicine at Stanford Hospital and Clinics to provide supportive care for cancer patients. The program included yoga, massage, and qigong classes and the study involved 398 patients over a nine-week period. According to the report, more than 90% of the patients reported overall improvement in quality of life with the program.

References
  1. Bower JE, Woolery A, Sternlieb B, et al. Yoga for cancer patients and survivors. Cancer Control. Jul 2005;12(3):165-171.
  2. Garfinkel MS, Singhal A, Katz WA, et al. Yoga-based intervention for carpal tunnel syndrome: a randomized trial. JAMA. Nov 11 1998;280(18):1601-1603.
  3. Kuttner L, Chambers CT, Hardial J, et al. A randomized trial of yoga for adolescents with irritable bowel syndrome. Pain Res Manag. Winter 2006;11(4):217-223.
  4. Manocha R, Marks GB, Kenchington P, et al. Sahaja yoga in the management of moderate to severe asthma: a randomised controlled trial. Thorax. Feb 2002;57(2):110-115.
  5. Rajesh B, Jayachandran D, Mohandas G, et al. A pilot study of a yoga meditation protocol for patients with medically refractory epilepsy. J Altern Complement Med. May 2006;12(4):367-371.
  6. Kristal AR, Littman AJ, Benitez D, et al. Yoga practice is associated with attenuated weight gain in healthy, middle-aged men and women. Altern Ther Health Med. Jul-Aug 2005;11(4):28-33.
  7. Malhotra V, Singh S, Tandon OP, et al. The beneficial effect of yoga in diabetes. Nepal Med Coll J. Dec 2005;7(2):145-147.
  8. John PJ, Sharma N, Sharma CM, et al. Effectiveness of yoga therapy in the treatment of migraine without aura: a randomized controlled trial. Headache. May 2007;47(5):654-661.
  9. Barnes PM, Powell-Griner E, McFann K, et al. Complementary and alternative medicine use among adults: United States, 2002. Adv Data. May 27 2004(343):1-19.
  10. Sharma H, Shekhawat NS, Bhandari S, et al. Rectus sheath haematoma: a rare presentation of non-contact strenuous exercises. Br J Sports Med. Oct 2007;41(10):688-690.
  11. Kirkwood G, Rampes H, Tuffrey V, et al. Yoga for anxiety: a systematic review of the research evidence. Br J Sports Med. Dec 2005;39(12):884-891; discussion 891.
  12. Streeter CC, Jensen JE, Perlmutter RM, et al. Yoga Asana Sessions Increase Brain GABA Levels: A Pilot Study. J Altern Complement Med. May 2007;13(4):419-426.
  13. Posadzki P, Ernst E. Yoga for low back pain: a systematic review of randomized clinical trials. Clin Rheumatol. Sep 2011;30(9):1257-1262.
  14. Shannahoff-Khalsa DS. Patient perspectives: Kundalini yoga meditation techniques for psycho-oncology and as potential therapies for cancer. Integr Cancer Ther. Mar 2005;4(1):87-100.
  15. Carson JW, Carson KM, Porter LS, et al. Yoga for women with metastatic breast cancer: results from a pilot study. J Pain Symptom Manage. Mar 2007;33(3):331-341.
  16. Moadel AB, Shah C, Wylie-Rosett J, et al. Randomized controlled trial of yoga among a multiethnic sample of breast cancer patients: effects on quality of life. J Clin Oncol. Oct 1 2007;25(28):4387-4395.
  17. Culos-Reed SN, Carlson LE, Daroux LM, et al. A pilot study of yoga for breast cancer survivors: physical and psychological benefits. Psychooncology. Oct 2006;15(10):891-897.
  18. Bower JE, Garet D, Sternlieb B, et al. Yoga for persistent fatigue in breast cancer survivors: A randomized controlled trial. Cancer. Dec 16 2011.
  19. Carson JW, Carson KM, Porter LS, et al. Yoga of Awareness program for menopausal symptoms in breast cancer survivors: results from a randomized trial. Support Care Cancer. Oct 2009;17(10):1301-1309.
  20. Cohen L, Warneke C, Fouladi RT, et al. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer. May 15 2004;100(10):2253-2260.
  21. Rosenbaum E, Gautier H, Fobair P, et al. Cancer supportive care, improving the quality of life for cancer patients. A program evaluation report. Support Care Cancer. May 2004;12(5):293-301.
  22. Rao MR, Raghuram N, Nagendra HR, et al. Anxiolytic effects of a yoga program in early breast cancer patients undergoing conventional treatment: a randomized controlled trial. Complement Th r Med. Jan 2009;17(1):1-8.
  23. Vadiraja HS, Raghavendra RM, Nagarathna R, et al. Effects of a yoga program on cortisol rhythm and mood states in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial. Integr Cancer Ther. Mar 2009;8(1):37-46.
  24. Carlson LE, Speca M, Patel KD, et al. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology. May 2004;29(4):448-474.
  25. Choi Y, Lee D. A case of rectus sheath hematoma caused by yoga exercise. Am J Emerg Med. Sep 2009;27(7):899 e891-892.
  26. de Barros DS, Bazzaz S, Gheith ME, et al. Progressive optic neuropathy in congenital glaucoma associated with the Sirsasana yoga posture. Ophthalmic Surg Lasers Imaging. Jul-Aug 2008;39(4):339-340.
  27. Gallardo MJ, Aggarwal N, Cavanagh HD, et al. Progression of glaucoma associated with the Sirsasana (headstand) yoga posture. Adv Ther. Nov-Dec 2006;23(6):921-925.
  28. Bertschinger DR, Mendrinos E, Dosso A. Yoga can be dangerous—glaucomatous visual field defect worsening due to postural yoga. Br J Ophthalmol. Oct 2007;91(10):1413-1414.
  29. Reutter D, Hunziker R, Husmann M. Computed angiogram of the upper extremities for diagnosing a rare cause of brachial arterial embolism: the 'Pitcher Syndrome'. Eur Heart J. Nov 2010;31(22):2782.
  30. Patel SC, Parker DA. Isolated rupture of the lateral collateral ligament during yoga practice: a case report. J Orthop Surg (Hong Kong). Dec 2008;16(3):378-380.
  31. Kashyap AS, Anand KP, Kashyap S. Complications of yoga. Emerg Med J. Mar 2007;24(3):231.
  32. Johnson DB, Tierney MJ, Sadighi PJ. Kapalabhati pranayama: breath of fire or cause of pneumothorax? A case report. Chest. May 2004;125(5):1951-1952.
  33. Lakkireddy D, Atkins D, Pillarisetti J, et al. Effect of Yoga on Arrhythmia Burden, Anxiety, Depression, and Quality of Life in Paroxysmal Atrial Fibrillation: The YOGA My Heart Study. J Am Coll Cardiol. 2013 Jan 25.

Consumer Information

How It Works

Bottom Line: Yoga improves quality of life in cancer patients and survivors by reducing stress, fatigue, and by improving sleep and mood.

Yoga is an ancient Indian philosophy that has been practiced for thousands of years. It involves regulated breathing, moving through various postures, and meditation, to achieve physical and emotional health benefits. Yoga was shown to reduce symptoms of carpal tunnel syndrome, irritable bowel syndrome, asthma, seizures, diabetes, migraine headaches, AIDS, depression, and it is also practiced for weight maintenance. Cancer patients and survivors reported better sleep, less stress, and improvement in overall quality of life with practice of yoga. It is now being offered in many cancer hospitals around the country.
Cancer patients interested in beginning yoga should first ask their physicians, because certain cancer treatments can cause physical limitations. The proper techniques should be learned from certified instructors who have experience working with cancer patients.

Purported Uses
  • Sleep quality
    Yoga was shown to improve overall sleep quality in some studies.
  • Stress
    Several studies support use of yoga to reduce stress.
  • Pain
    Yoga was shown in some studies to relieve pain.
  • Depression
    Some studies have linked yoga to reduce depression and result in a positive mood.
  • Fatigue
    A study found Yoga can help reduce fatigue and improve vigor in breast cancer survivors
Research Evidence

Cancer:
A clinical study found yoga can reduce fatigue in breast cancer survivors. Thirty-one women were randomly assigned to practice yoga for 12-week or to health education as control. Fatigue severity declined significantly in the yoga group as compared to the controls. The yoga group also had significant increases in vigor.

Thirty-nine patients with lymphoma were assigned to participate in Tibetan yoga or control group for seven weeks. Researchers report that patients in the Tibetan yoga group reported overall improvement in sleep quality and less use of sleep medications compared to those in the control group.

Another study of 398 cancer patients at the Stanford Cancer Supportive Care Program that offered massage, yoga, and qigong to the patients. After nine weeks of participation, more than 90% of patients reported increased sense of well-being.

Patient Warnings

Pregnant women and individuals with hypertension or glaucoma should use caution when practicing certain yoga postures.

Side Effects

Side effects from yoga are rare. However, blood clots, nerve damage, torn ligament and difficulty breathing have been reported.

Special Point

You are pregnant or have physical limitations (certain yoga techniques may not be advisable.)

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