Zestra is a topical botanical formulation of borage seed oil, evening primrose oil, angelica root extract, Coleus forskohlii extract, ascorbyl palmitate, and dl-alpha tocopherol. It is being promoted to relieve symptoms associated with female sexual dysfunction. Sexual dysfunction may involve painful intercourse, loss of libido, difficulty in maintaining arousal, or difficulty in achieving orgasm. It may be caused by factors such as stress, hormonal changes, cancer treatment involving surgery, radiation, chemotherapy or hormone therapy, use of antidepressants, or menopause. Use of Zestra results in increased clitoral and vaginal warmth, heightened arousal, and increased sexual pleasure. The borage, primrose, angelica, and coleus extracts may contribute to Zestra's activity by increasing blood flow and nerve conduction (2) (3) (4). Clinical studies show that Zestra benefits both normal women and those with sexual disorders (1) (6).
Zestra has not been studied in cancer patients. Adverse effects from use of Zestra include mild burning sensation locally. It is contraindicated in women who are pregnant, breastfeeding, and in those trying to conceive.