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Aldesleukin (al des LOO kin)

Pediatric Medication

Brand Names: U.S.

Proleukin

Brand Names: Canada

Proleukin

Warning

  • This drug is only to be used in people with good heart and lung function. Tell your child’s doctor if your child has ever had any heart or lung disease.
  • This drug may cause a very bad and sometimes deadly problem called capillary leak syndrome (CLS). CLS may lead to low blood pressure and harm to the organs. It may also lead to a heartbeat that is not normal, chest pain or pressure, heart attack, lung or breathing problems, bleeding or lower blood flow in the stomach or bowel, kidney problems, swelling, or change in thinking clearly and with logic. Talk with the doctor.
  • This drug may raise the chance of getting a very bad infection. If your child has an infection, it needs to be treated before getting this drug. If your child has any infection, has been taking antibiotics now or in the recent past, or has had many infections, talk with the doctor.
  • Tell your child’s doctor right away if your child feels very sleepy or weak. This drug may need to be stopped.

What is this drug used for?

  • It is used to treat kidney cancer.
  • It is used to treat skin cancer.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has had a transplant.
  • If your child has had any of these health problems with this drug in the past: Bleeding or lower blood flow in the stomach or bowel, chest pain, coma, dialysis, a fast heartbeat, a heartbeat that does not feel normal, heart problems like heart attack, hole in the GI (gastrointestinal) tract, lung or breathing problems, mental problems, or seizures.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of their drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • Have your child’s heart and lung function checked. Talk with your child’s doctor.
  • If your child has high blood sugar (diabetes), you will need to watch his/her blood sugar closely.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
  • If your child is having an x-ray or scan with dye, talk with the doctor.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Signs of kidney problems like unable to pass urine, change in the amount of urine passed, blood in the urine, or a big weight gain.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • If your child shows signs of low mood (depression), thoughts of killing him/herself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • A heartbeat that does not feel normal.
  • Chest pain or pressure or a fast heartbeat.
  • Very bad dizziness or passing out.
  • Shortness of breath, a big weight gain, swelling in the arms or legs.
  • Throwing up blood or throw up that looks like coffee grounds.
  • Black, tarry, or bloody stools.
  • Swelling of belly.
  • Change in thinking clearly and with logic.
  • Mouth irritation or mouth sores.
  • Very bad belly pain.
  • Hallucinations.
  • Trouble speaking.
  • Trouble walking.
  • Change in balance.
  • Loss of eyesight.
  • Any bruising or bleeding.
  • Feeling very tired or weak.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if your child has signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Dizziness.
  • Upset stomach or throwing up.
  • Anxiety.
  • Not hungry.
  • Belly pain.
  • Loose stools (diarrhea).
  • Runny nose.
  • Weight gain.
  • Feeling tired or weak.
  • Feeling sleepy.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read and follow the dosing on the label closely.
  • It is given into a vein for a period of time.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • This drug will be given to your child in a hospital or doctor’s office. You will not store it at home.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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