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Asparaginase (E. coli) (a SPEAR a ji nase e ko lye)

Adult Medication

Brand Names: Canada

Kidrolase

Warning

  • Allergic reactions may happen with this drug. The chance of an allergic reaction is higher in people who have had an allergic reaction to a drug like this one. Talk with the doctor.
  • This drug may cause liver problems in some people. In patients who already have liver problems, it may make them worse. Talk with the doctor.

What is this drug used for?

  • It is used to treat a type of leukemia.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to asparaginase or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Liver problems or pancreatitis.
  • If you have had a recent yellow fever vaccine.
  • If this drug caused bleeding, a blood clot, or an irritated pancreas before.
  • If you are pregnant or may be pregnant. Do not use this drug if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take this drug.
  • If you are taking any of these drugs: Fosphenytoin or phenytoin.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Very bad bleeding and blood clots in the brain have happened with this drug and other drugs like it. Talk with the doctor.
  • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of an infection or make the vaccine not work as well.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • If you have high blood sugar (diabetes), talk with your doctor. This drug may raise blood sugar.
  • Check your blood sugar as you have been told by your doctor.
  • A very bad and sometimes deadly pancreas problem (pancreatitis) has happened with this drug. Talk with your doctor.
  • This drug may stop menstrual periods in females and affect sperm in males. Talk with the doctor.
  • This drug may cause harm to the unborn baby if you take it while you are pregnant. If you get pregnant while taking this drug, call your doctor right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of infection. These include a fever of 100.4°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Signs of kidney problems like unable to pass urine, change in the amount of urine passed, blood in the urine, or a big weight gain.
  • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Change in thinking clearly and with logic.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Chest pain or pressure.
  • Shortness of breath.
  • Very bad headache.
  • Feeling very tired or weak.
  • Very bad dizziness or passing out.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
  • It is given as a shot into a muscle or vein.

What do I do if I miss a dose?

  • Call the doctor to find out what to do.

How do I store and/or throw out this drug?

  • This drug will be given to you in a hospital or doctor’s office. You will not store it at home.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2015-02-23

Copyright

Copyright © 2014 Clinical Drug Information, LLC and Lexi-Comp, Inc.