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Bevacizumab (be vuh SIZ uh mab)

Pediatric Medication

Brand Names: U.S.

Avastin

Brand Names: Canada

Avastin

Warning

  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract or fistulas have happened with this drug. Talk with the doctor.
  • Very bad and sometimes deadly bleeding problems have happened with this drug. Talk with the doctor.
  • Do not give this drug if your child has very bad bleeding or if your child has thrown up recently.
  • This drug may affect how wounds heal. If your child needs to have surgery, you may need to stop giving this drug before surgery. Start giving it again after surgery as you have been told by the doctor. Talk with the doctor.

What is this drug used for?

  • It is used to treat cancer.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If this drug is being used to treat ovarian cancer and the cancer is also in certain parts of your child’s bowels or your child has bowel blockage.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of their drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with this drug. Talk with the doctor.
  • Blood clots have happened with this drug. Sometimes, blood clots like heart attack and stroke have been deadly. Talk with the doctor.
  • If your child has an upset stomach or loose stools (diarrhea), is throwing up, or is not hungry, talk with the doctor. There may be ways to lower these side effects.
  • If your child has high blood sugar (diabetes), you will need to watch his/her blood sugar closely.
  • This drug may cause high blood pressure.
  • Have your child’s blood pressure checked often. Talk with your child’s doctor.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • Have your child’s urine checked. Talk with your child’s doctor.
  • Some patients have very bad side effects during the infusion. Tell your child’s doctor if your child has any bad effects during the infusion.
  • A very bad and sometimes deadly health problem called fistula has rarely happened with this drug. Talk with the doctor.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • This drug may cause your child to not be able to get pregnant later in life. Talk with the doctor.

If your child is or may be sexually active:

  • Have your child use birth control to prevent pregnancy while taking this drug and for 6 months after stopping this drug.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of infection. These include a fever of 100.4°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Chest pain or pressure.
  • Very bad dizziness or passing out.
  • Shortness of breath, a big weight gain, swelling in the arms or legs.
  • Very bad headache.
  • Seizures.
  • Change in thinking clearly and with logic.
  • Loss of eyesight.
  • Very upset stomach or throwing up.
  • Very hard stools (constipation).
  • Very bad belly pain.
  • Skin wound that will not heal.
  • Mouth irritation or mouth sores.
  • Change in eyesight.
  • Not able to pass urine or change in how much urine is passed.
  • Sweating a lot.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Dizziness.
  • Headache.
  • Belly pain.
  • Back pain.
  • Muscle pain.
  • Hard stools (constipation).
  • Loose stools (diarrhea).
  • Upset stomach or throwing up.
  • Feeling tired or weak.
  • Not hungry.
  • Hair loss.
  • Dry skin.
  • Change in taste.
  • Weight loss.
  • Dry mouth.
  • Change in voice.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read and follow the dosing on the label closely.
  • It is given as a shot into a vein over a period of time.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • This drug will be given to your child in a hospital or doctor’s office. You will not store it at home.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2014-12-04

Copyright

Copyright © 2014 Clinical Drug Information, LLC and Lexi-Comp, Inc.