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Bupropion (byoo PROE pee on)

Brand Names: U.S.

Aplenzin; Budeprion SR [DSC]; Buproban; Forfivo XL; Wellbutrin; Wellbutrin SR; Wellbutrin XL; Zyban

Brand Names: Canada

Ava-Bupropion SR; Bupropion SR; Mylan-Bupropion XL; Novo-Bupropion SR; PMS-Bupropion SR; ratio-Bupropion SR; Sandoz-Bupropion SR; Wellbutrin SR; Wellbutrin XL; Zyban

Warning

  • Children and teens who take this drug may be at a greater risk of having thoughts or actions of suicide. Adults may also be at risk. The risk may be greater in people who have had these thoughts or actions in the past. Watch people who take this drug closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • This drug is not approved for use in children. Talk with your doctor.
  • Not all products are approved for use to help you stop smoking. Talk with your doctor to make sure that you have the right product.
  • When used to stop smoking this drug may cause or make diseases of the mind worse. Taking one’s own life, ideas of killing yourself or murder, low mood (depression), forceful actions, hallucinations, and psychoses have happened with use. If you think you have any of these problems, call your doctor right away.

What is this drug used for?

  • It is used to treat low mood (depression).
  • It is used to help you stop smoking.
  • It is used to treat seasonal affective disorder (SAD).
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to bupropion or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have ever had any of these health problems: Eating problem or seizures.
  • If you drink a lot of beer, wine, or mixed drinks and you stop drinking all of a sudden.
  • If you use certain other drugs or natural products that slow your actions (like drugs for seizures or anxiety) and you stop using them all of a sudden.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson’s disease like selegiline or rasagiline in the last 14 days. Taking this drug within 14 days of those drugs can cause very bad high blood pressure. Talk with your doctor.
  • If you are taking any of these drugs: Linezolid or methylene blue.
  • If you are taking another drug that has the same drug in it.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
  • This drug may affect certain lab tests. Be sure your doctor and lab workers know you take this drug.
  • Do not stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor.
  • This drug may cause high blood pressure.
  • Have your blood pressure checked often. Talk with your doctor.
  • This drug may raise the chance of seizures. The chance may be higher in people who have certain health problems, use certain other drugs, or drink a lot of beer, wine, or mixed drinks. Talk to your doctor to see if you have a greater chance of seizures while taking this drug.
  • Avoid beer, wine, or mixed drinks.
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • It may take several weeks to see the full effects.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Zyban:

  • If you have not been able to quit smoking after taking this drug for 12 weeks, talk with your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Change in how you act.
  • Change in thinking clearly and with logic.
  • Hallucinations.
  • Restlessness.
  • Very bad headache.
  • Very nervous and excitable.
  • If seizures are new or worse after starting this drug.
  • A big weight gain or loss.
  • Chest pain or pressure.
  • A heartbeat that does not feel normal.
  • Ringing in ears.
  • Change in eyesight.
  • Passing urine often.
  • Swollen gland.
  • Trouble moving around.
  • Very bad muscle or joint pain.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Dizziness.
  • Feeling sleepy.
  • Headache.
  • Belly pain.
  • Shakiness.
  • Feeling nervous and excitable.
  • Bad dreams.
  • Upset stomach or throwing up.
  • Hard stools (constipation).
  • Dry mouth.
  • Loose stools (diarrhea).
  • Not able to sleep.
  • Muscle pain.
  • Nose and throat irritation.
  • Sweating a lot.
  • Not hungry.
  • A change in weight without trying.

Extended-release tablets:

  • You may see the tablet shell in your stool.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

All products:

  • To gain the most benefit, do not miss doses.
  • Take as you have been told, even if you feel well.
  • Take this drug at the same time of day.
  • Take with or without food. Take with food if it causes an upset stomach.
  • If you are not able to sleep, do not take this drug too close to bedtime. Talk with your doctor.
  • Swallow whole. Do not chew, break, or crush.

Zyban:

  • You may take this drug for 1 week before you stop smoking.
  • Nicotine products and counseling may be used at the same time for best results.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only your healthcare provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your healthcare provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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