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Clozapine (KLOE za peen)

Adult Medication

Brand Names: U.S.

Clozaril; FazaClo; Versacloz

Brand Names: Canada

Apo-Clozapine; Clozaril; Gen-Clozapine

Warning

  • This drug may lower the ability of your bone marrow to make white blood cells. This can lead to very bad and sometimes deadly infections. Because of this, use this drug only if your health problem has not been helped by other drugs or if you have planned to harm yourself in the past and have a chance of doing it again. You will need to have your blood work checked before treatment, during treatment, and for at least 4 weeks after treatment is stopped. Do what the doctor tells you about blood tests while taking this drug.
  • You may only get this drug through a special program. Talk with your doctor.
  • This drug may cause seizures in some people. The chance of seizures may be higher with higher doses or if you have ever had seizures. Use care when driving and doing other tasks or actions (like climbing and swimming) that may not be safe for you or others if you pass out.
  • This drug may raise the chance of a very bad and sometimes deadly heart problem (myocarditis). Most of the time, these heart problems have happened within the first 2 months of care but may happen at any time. Call your doctor right away if you have a big weight gain, a heartbeat that does not feel normal, chest pain or pressure, fast heartbeat, fever, flu-like signs, shortness of breath, swelling in the arms or legs, or very bad dizziness or passing out.
  • Low blood pressure, passing out, slow heartbeat, and heart attacks have happened with this drug. These problems can be deadly. The chance of these problems is highest when this drug is first started. Do not take more than you were told or raise your dose faster than you were told. Tell your doctor if you have heart problems (like if you have ever had a heart attack, blood vessel problems, heart failure, or a heartbeat that is not normal) or brain problems. Tell your doctor if you have lots of fluid loss or if you take drugs for high blood pressure.
  • There is a higher chance of death in older adults who take this drug for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This drug is not approved to treat mental problems caused by dementia.

What is this drug used for?

  • It is used to treat schizophrenia.
  • It is used to treat problems with how one acts.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to clozapine or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have a low white blood cell count.
  • If you have any of these health problems: Low potassium or magnesium levels.
  • If you have ever had a low white blood cell count when taking this drug before.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • If you have high blood sugar (diabetes), talk with your doctor. This drug may raise blood sugar.
  • Check your blood sugar as you have been told by your doctor.
  • Have your blood work checked often. Talk with your doctor.
  • Have a heart function test. Talk with your doctor.
  • If you start or stop smoking, talk with your doctor. How much drug you take may need to be changed.
  • Blood clots have happened with this drug. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
  • Talk with your doctor before you drink beer, wine, mixed drinks, or use other drugs and natural products that slow your actions.
  • Tell your doctor if you use caffeine products (for example, tea, coffee, cola) and chocolate. How much of this drug you take may need to be changed.
  • Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
  • Women and people with a Jewish background may have a higher chance of blood problems with this drug. Talk with your doctor.
  • This drug can cause very bad and sometimes deadly stomach or bowel problems like very hard stools (constipation) or bowel block. To help avoid these problems, drink lots of noncaffeine liquids unless told to drink less liquid by your doctor. Laxatives may also help. Talk with your doctor.
  • This drug may cause weight gain. You may need to have your weight checked often.
  • Do not stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor.
  • Older adults with dementia taking drugs like this one have had a higher number of strokes. Sometimes these strokes have been deadly. This drug is not approved to treat mental problems caused by dementia. Talk with your doctor.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Taking this drug in the third trimester of pregnancy may lead to muscle movements that cannot be controlled and withdrawal in the newborn. Talk with the doctor.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Oral-disintegrating tablet:

  • If you have PKU, talk with your doctor. Some products have phenylalanine.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
  • Shakiness, trouble moving around, or stiffness.
  • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Coughing up blood.
  • Blue or very pale skin in the arms or legs.
  • Very bad headache.
  • Seizures.
  • Feeling very tired or weak.
  • Change in thinking clearly and with logic.
  • Slow heartbeat.
  • Very hard stools (constipation).
  • Change in eyesight.
  • A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
  • Some people who take this drug may get a very bad muscle problem called tardive dyskinesia. The risk may be greater in older adults, mainly women. The chance that this will happen or that it will never go away is greater in people who take this drug in higher doses or for a long time. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Dizziness.
  • Feeling sleepy.
  • Hard stools (constipation).
  • Dry mouth.
  • Upset stomach or throwing up.
  • Weight gain.
  • Not able to sleep.
  • Drooling.
  • Headache.
  • Sweating a lot.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

All products:

  • Take with or without food.
  • Take as you have been told, even if you feel well.
  • To gain the most benefit, do not miss doses.

Oral-disintegrating tablet:

  • Do not push the tablet out of the foil when opening. Use dry hands to take it from the foil. Place on your tongue and let it melt. Water is not needed. Do not swallow it whole. You may chew the tablet.

Liquid (suspension):

  • Shake well before use.
  • Measure liquid doses carefully. Use the measuring device that comes with this drug.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you miss 2 or more days of this drug, call your doctor to find out how to restart.

How do I store and/or throw out this drug?

All products:

  • Store at room temperature. Do not refrigerate or freeze.
  • Store in a dry place. Do not store in a bathroom.
  • Protect from light.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Oral-disintegrating tablet:

  • Store in pouch until ready for use.
  • Use oral-disintegrating tablet right after opening. Throw away any part of opened pouch that is not used.

Liquid (suspension):

  • Throw away any part not used 100 days after opening the first time.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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