Brand Names: U.S.
- This drug may harm the tubes in the penis. This damage may not go away. It may cause them to break during an erection. This drug may also cause blood vessels in the penis to break. This may cause blood to collect under the skin. Call your doctor right away if you are not able to keep an erection all of a sudden. Call your doctor right away if you have pain, bruising, or swelling of the penis; a popping sound or feeling in an erect penis; trouble passing urine; or blood in the urine.
- You may only get this drug through the Xiaflex REMS program.
What is this drug used for?
- It is used to treat cords formed in patients with Dupuytren’s contracture.
- It is used to treat Peyronie’s disease.
What do I need to tell my doctor BEFORE I take this drug?
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- If you have an allergy to collagenase or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have Peyronie’s disease and the plaque to be treated is in the urethra (the tube that urine passes through).
What are some things I need to know or do while I take this drug?
- Tell dentists, surgeons, and other doctors that you use this drug.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Do not have sex or any other sex action for at least 2 weeks after the second dose and until any pain and swelling have gone away.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
- Chest pain.
- Very bad swelling or pain of hands or feet.
- A burning, numbness, or tingling feeling that is not normal.
- Damage to a tendon or ligament causing the tendon or ligament to be weak or break has happened with this drug. Surgery may be needed to fix this. Call your doctor right away if you are not able to bend the treated finger after the swelling goes down or if you have any problems using your treated hand.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Irritation or swelling where the shot was given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
- Mild pain in the penis. OTC pain drugs may help.
How is this drug best taken?
Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
- It is given as a shot.
- Your doctor will give this drug.
- Do not bend or straighten the fingers of your treated hand until your doctor tells you it is okay.
- Do not try to straighten your treated finger.
- Keep your treated hand raised until bedtime on the first day.
- You will need to go back to your doctor’s office the next day.
- You will be given a splint to wear on the treated finger at bedtime for up to 4 months.
- Do your finger exercises each day.
- Do not start normal actions with the treated hand until doctor tells you it is okay.
- Your doctor will give you a patient guide that tells you how to stretch and form your penis at home. Read it carefully.
- Follow how and when to stretch your penis after each cycle as your doctor has told you.
What do I do if I miss a dose?
- Call the doctor to find out what to do.
How do I store and/or throw out this drug?
- This drug will be given to you in a hospital or doctor’s office. You will not store it at home.
- Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
General drug facts
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Consumer Information Use and Disclaimer
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
Copyright © 2014 Clinical Drug Information, LLC and Lexi-Comp, Inc.
Last updated: October 11, 2014