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Doxorubicin (Liposomal) (doks oh ROO bi sin lye po SO mal)

Adult Medication

Brand Names: U.S.

Doxil; Lipodox; Lipodox 50

Brand Names: Canada

Caelyx; Myocet

Warning

  • This drug may cause very bad and sometimes deadly heart problems. This can happen during care or months to years after you get this drug. Sometimes, these heart problems will not go away. The chance of heart problems may be raised if you are using other drugs that may cause heart problems or if you have ever had heart problems or radiation to the chest area, or if you have ever had this drug or other drugs like this one. Ask your doctor if you are not sure if any drugs you take may cause heart problems. Your chance of heart problems depends on your dose of this drug and your health problem. Heart problems may happen even if you do not have any risk factors. Call your doctor right away if you have cough, fast or slow heartbeat, a heartbeat that does not feel normal, swelling in the arms or legs, shortness of breath, sudden weight gain, or feeling very tired or weak.
  • This drug may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
  • You will be watched closely by your doctor.
  • If you have liver disease you may need a lower dose. Talk with your doctor.
  • Side effects like flushing, shortness of breath, swelling of the face, headache, chills, back pain, chest or throat tightness, and very bad dizziness or passing out have happened with this drug during the infusion. Most of the time, these side effects happen with the first infusion and have gone away within a few hours to a day after the infusion is stopped. Sometimes, these reactions have been very bad and even life-threatening or deadly. Tell your doctor right away if you have any of these signs.

What is this drug used for?

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to doxorubicin or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • To help with mouth sores, use a soft toothbrush or cotton swabs and rinse the mouth. Do not use mouth rinses that have alcohol in them.
  • If you have had daunorubicin, doxorubicin, epirubicin, idarubicin, or mitoxantrone before, talk with your doctor.
  • This drug may add to the chance of getting some types of cancer. Talk with the doctor.
  • Cases of mouth cancer have happened in people who have used this drug long-term (more than 1 year). These cancers have happened during care with this drug and up to 6 years after the last dose. Your doctor will check your mouth during care with this drug. Call your doctor right away if you have mouth pain, sores, or ulcers.
  • Have your blood work checked often. Talk with your doctor.
  • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of an infection or make the vaccine not work as well.
  • This drug may affect sperm in men. This may affect being able to father a child. Talk with the doctor.
  • This drug may cause you to not be able to get pregnant. Talk with the doctor.
  • This drug may cause harm to the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust to prevent pregnancy while taking this drug.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy. Use birth control that you can trust.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Chest pain or pressure.
  • Very upset stomach or throwing up.
  • A big weight loss.
  • Bone pain.
  • Night sweats.
  • Any bruising or bleeding.
  • A burning, numbness, or tingling feeling that is not normal.
  • Redness or irritation of the palms of hands or soles of feet.
  • Feeling very tired or weak.
  • Very bad skin irritation.
  • Blood in the urine.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Feeling tired or weak.
  • Hard stools (constipation).
  • Loose stools (diarrhea).
  • Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating. Mild pain drugs may help.
  • Upset stomach or throwing up.
  • Not hungry.
  • Mouth and lip irritation.
  • Back pain.
  • Headache.
  • Hair loss.
  • Urine and other body fluids may change to an orange or red color. This is normal.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
  • It is given as a shot into a vein over a period of time.

What do I do if I miss a dose?

  • Call the doctor to find out what to do.

How do I store and/or throw out this drug?

  • This drug will be given to you in a hospital or doctor’s office. You will not store it at home.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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