This information will help you prepare for your endometrial biopsy at Memorial Sloan Kettering Cancer Center (MSK).

During your endometrial biopsy, your doctor will remove a small piece of tissue from the lining of your uterus (endometrium). This tissue is then examined under a microscope to look for abnormal cells or signs of cancer.

Before Your Procedure

Tell your doctor or nurse if you are allergic to iodine or latex, or if there is a chance that you may be pregnant.

You do not need to do anything to prepare for this procedure.

During Your Procedure

Your doctor will do the endometrial biopsy in an exam room. It will take about 5 minutes.

You will lie on your back with your feet in stirrups. This is the same position you are in for routine pelvic exams.

Your doctor will insert a tool (speculum) into your vagina to hold it open. This allows your doctor to see your cervix, which is located at the end of your uterus.

Your doctor will clean your cervix with a cool, brown solution of povidone-iodine (Betadine®). He or she will put a thin, flexible tool through the speculum into your uterus and take a small amount of tissue from your endometrium. You will feel some cramping as the tissue is removed.

After Your Procedure

  • You may have a small amount of vaginal spotting or bleeding. This may last for several days after the procedure.
  • If your doctor approves, you can take medication for the cramping such as ibuprofen (Advil®). You can buy it at a drug store without a prescription.
  • Do not douche for 48 hours unless your doctor tells you differently.
  • Speak with your doctor or nurse about when it is safe for you to resume vaginal intercourse.

Call Your Doctor or Nurse if You Have:

  • A temperature of 101° F (38.3° C) or higher
  • Vaginal bleeding that is heavier than your menstrual flow
  • Pain that does not get better after taking medication for cramping
  • Any unexpected problems