Brand Names: U.S.
Estrace; Estring; Vagifem
Brand Names: Canada
Estrace®; Estring®; Vagifem®; Vagifem® 10
- Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to your doctor.
- Do not take estrogens to prevent heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, a blood clot, or dementia.
- Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.
What is this drug used for?
- It is used to treat vaginal irritation and dryness caused by change of life.
- It is used to treat urinary signs caused by change of life.
What do I need to tell my doctor BEFORE I take this drug?
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- If you have an allergy to estradiol or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have had any of these health problems: Bleeding disorder, blood clots, a higher risk of having a blood clot, breast cancer, liver disease, heart attack, stroke, tumor where estrogen makes it grow, or vaginal bleeding where the cause is not known.
- If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
What are some things I need to know or do while I take this drug?
- Tell dentists, surgeons, and other doctors that you use this drug.
- If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
- Have your blood pressure checked often. Talk with your doctor.
- Do monthly breast self-exams and have a gynecologic exam every year.
- Have your blood work checked. Talk with your doctor.
- This drug may affect certain lab tests. Be sure your doctor and lab workers know you take this drug.
- Do not smoke. Smoking raises the chance of heart disease. Talk with your doctor.
- Limit your drinking of wine, beer, or mixed drinks.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- Talk with your doctor if you will need to be still for long periods of time like long trips, bed rest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
- If you are 65 or older, use this drug with care. You could have more side effects.
- This drug is not approved for use in children. Talk with the doctor.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Tell your doctor if you have trouble getting the ring out.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Chest pain or pressure.
- Shortness of breath.
- Coughing up blood.
- Swelling, warmth, numbness, change of color, or pain in a leg or arm.
- Very bad headache.
- Very bad dizziness or passing out.
- Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
- Very upset stomach or throwing up.
- Very bad belly pain.
- Very bad vaginal irritation.
- Vaginal itching or discharge.
- Vaginal bleeding that is not normal.
- A lump in the breast, breast soreness, or nipple discharge.
- Breast pain.
- Low mood (depression).
- Mood changes.
- Memory problems or loss.
- Bulging eyes.
- Change in how contact lenses feel in the eyes.
- Change in eyesight.
- Swelling in the feet or hands.
- Toxic shock syndrome (TSS) has happened in a few patients using vaginal rings. TSS is rare, but can be very bad and sometimes deadly. Tell your doctor right away if you have loose stools (diarrhea), dizziness or light-headedness, passing out, fever, muscle pain, upset stomach, throwing up, or a sunburn-like rash.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hair loss.
- Breast soreness.
- Upset stomach or throwing up.
- Vaginal bleeding or spotting.
- This drug may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
How is this drug best taken?
Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
- Take this drug at the same time of day.
- Follow how to use as you have been told by your doctor or read the package insert.
- Wash your hands before use.
- Wash your hands and applicator after use.
- There may be days when you will not take this drug.
- Put into the vagina and leave in place for 90 days.
- To use, wash your hands and take ring from the pouch.
- Be sure your hands are dry before you touch this drug.
- Press sides of ring at the same time between thumb and index finger and put folded ring into the vagina.
- Perfect placement is not needed for the ring to work. The ring will not hurt.
- If the ring comes out, rinse with lukewarm water and put back in.
- To take out, hook your index finger around the rim or hold rim between index finger and middle finger and pull out.
- Do not throw the vaginal ring in the toilet.
- Wash your hands after use.
What do I do if I miss a dose?
- Use a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not use 2 doses or extra doses.
How do I store and/or throw out this drug?
- Store at room temperature.
- Protect from heat.
- Store in original container.
- Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
General drug facts
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Consumer Information Use and Disclaimer
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
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