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Everolimus (e ver OH li mus)

Pediatric Medication

Brand Names: U.S.

Afinitor; Afinitor Disperz; Zortress

Brand Names: Canada

Afinitor

Warning

  • Long-term use may raise the chance of cancer and unsafe infections. Your child will be closely watched while taking this drug.
  • Sometimes drugs are not safe when your child takes them with other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your child’s doctor about all the drugs your child takes.

What is this drug used for?

  • It is used to treat a type of brain tumor.

Is it safe for my child to take this drug?

  • Not if your child has an allergy to everolimus, temsirolimus, sirolimus, or any other part of this drug.
  • Be sure to let the doctor know if your child has any allergies or side effects to drugs, foods, or dyes. Make sure to tell about the allergy and what signs your child had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • Not if your child takes any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for HIV, infections, or low mood (depression). There are many drugs that must not be taken with this drug.

What are some things I need to know or do while my child takes this drug?

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • The chance of cancer is higher after using this drug. Talk with the doctor.
  • If your child has high blood sugar (diabetes), talk with the doctor.
  • If your child has high cholesterol, talk with the doctor.
  • If your child is being treated for any infection, talk with the doctor.
  • If your child has liver disease, talk with the doctor.
  • Have your child’s blood work checked. Talk with your child’s doctor.
  • Check all drugs your child is taking with your child’s doctor. This drug may not mix well with some other drugs.
  • Avoid giving your child grapefruit and grapefruit juice.
  • Your child may get sunburned more easily. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and dress your child in clothing and eyewear that protects him/her from the sun.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • Make sure your child avoids being near anyone who has had a recent live vaccine. There are many types of live vaccines. Ask your doctor or pharmacist if you are not sure.
  • This drug may cause fertility problems. This may affect being able to have children. Talk with the doctor.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • If your child shows any signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color or sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Redness or irritation of the palms of hands or soles of feet.
  • If your child has weakness, numbness, or tingling.
  • If your child has chest pain or pressure.
  • If your child has very bad belly pain.
  • If your child has a very bad upset stomach or is throwing up.
  • If your child has very loose stools (diarrhea).
  • If your child has any bruising or bleeding.
  • If your child has very bad mouth irritation.
  • If your child has a fast heartbeat.
  • A heartbeat that does not feel normal.
  • If your child has a seizure.
  • If your child has very bad dizziness or passing out.
  • If your child has a very bad headache.
  • If your child is feeling very tired or weak.
  • Muscle pain or weakness.
  • Period (menstrual) changes. These may include a missed period.
  • Mood changes.
  • Change in the way your child acts.
  • Swelling.
  • If your child has very bad back pain.
  • If your child gets a rash.
  • This drug may affect how wounds heal. Sometimes, people with wound healing problems have needed surgery. Call the doctor right away if your child has a wound that is red, warm, painful, or swollen. Call the doctor right away if your child has a wound that opens up or if there is blood, fluid, or pus in a wound.
  • Very bad and sometimes deadly lung problems have happened with this drug. Call the doctor right away if your child has lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Very bad and sometimes deadly kidney problems have happened with this drug. Call the doctor right away if your child is unable to pass urine, has blood in the urine, or has a change in the amount of urine passed.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Anemia, low white blood cell count, and low platelet count.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • High cholesterol level.
  • High blood sugar. This most often goes back to normal when drug is stopped.
  • Swelling.
  • Feeling tired or weak.
  • Fever.
  • Rash.
  • Pimples (acne).
  • Dry skin.
  • Upset stomach or throwing up. Many small meals and good mouth care may help. Older children may suck hard, sugar-free candy.
  • Loose stools (diarrhea).
  • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
  • Mouth irritation or sores. Using a soft toothbrush or cotton swabs and rinsing the mouth may help. Do not use mouth rinses that have alcohol in them.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read and follow the dosing on the label closely.
  • To gain the most benefit, do not miss giving your child doses.
  • Give this drug at the same time of day.
  • Give this drug with or without food. If giving with food, always give with the same amount and kinds of food each time.

Tablet:

  • Give this drug with a full glass of water.
  • Have your child swallow whole. Do not let your child chew, break, or crush.

Disperz tablets:

  • Give as a liquid only. Do not let your child swallow tablets whole.
  • Wear gloves when touching this drug.
  • Mix with water as you have been told before drinking.
  • Have your child drink right after mixing. Throw away any part not used after 1 hour.

What do I do if my child misses a dose?

  • Give a missed dose as soon as you think about it.
  • If it has been 6 hours or more since the missed dose, skip the missed dose and go back to your child’s normal time.
  • Do not give 2 doses or extra doses.
  • Do not change the dose or stop your child’s drug. Talk with your child’s doctor.

How do I store and/or throw out this drug?

  • Store in the original container at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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